Evidence map›Paper›PMID 38012186›Full record

Observational studyScientific reports2023

Effect of routine suction on lung aeration in critically ill neonates and young infants measured with electrical impedance tomography.

Claas Händel, Tobias Becher, Martijn Miedema, Merja Kallio, Thalia Papadouri, Andreas D Waldmann, Louiza Sophocleous, Christina Karaoli, Rebecca Yerworth, Richard Bayford and 3 more

Registry-linked trialOpen access · goldAbstract readObservational StudyMulticenter Study
In one paragraph

Observational study in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07494006 (Association Between Spontaneous Breathing Mode and Hypoxemia During One-Lung Ventilation Under General Anesthesia), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07494006 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Association Between Spontaneous Breathing Mode and Hypoxemia During One-Lung Ventilation Under General Anesthesia

TypeobservationalSponsorPeking University People's HospitalRan2025 to 2026Enrolled44ConditionsLung Cancer, OLV, Hypoxemia During Surgery
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 6 countries.

Claas HändelDepartment of Anaesthesiology and Intensive Care Medicine, University Medical Center Schlewig-Holstein, Campus Kiel, Kiel, Germany. claas.strodthoff@uksh.de.
Tobias BecherDepartment of Anaesthesiology and Intensive Care Medicine, University Medical Center Schlewig-Holstein, Campus Kiel, Kiel, Germany.
Martijn MiedemaDepartment of Neonatology, Emma Children's Hospital, Amsterdam UMC, Amsterdam, The Netherlands.
Merja KallioDepartment of Pediatrics and Adolescent Medicine, Oulu University Hospital, and Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland.
Thalia PapadouriNeonatal Intensive Care Unit, Arch. Makarios III Hospital, Nicosia, Cyprus.
Andreas D WaldmannDepartment of Anesthesiology and Intensive Care Medicine, University Medical Center Rostock, Rostock, Germany.
Louiza SophocleousDepartment of Electrical and Computer Engineering, KIOS Research Center, University of Cyprus, Nicosia, Cyprus.
Christina KaraoliNeonatal Intensive Care Unit, Arch. Makarios III Hospital, Nicosia, Cyprus.
Rebecca YerworthMedical Physics and Biomedical Engineering Department, University College London, London, UK.
Richard BayfordDepartment of Natural Sciences, Middlesex University, London, UK.
Peter C RimensbergerDivision of Neonatology and Pediatric Intensive Care, University Hospital of Geneva, University of Geneva, Geneva, Switzerland.
Anton H van KaamDepartment of Neonatology, Emma Children's Hospital, Amsterdam UMC, Amsterdam, The Netherlands.
Inéz FrerichsDepartment of Anaesthesiology and Intensive Care Medicine, University Medical Center Schlewig-Holstein, Campus Kiel, Kiel, Germany.
Amsterdam University Medical Centers · NLArchbishop Makarios III Hospital · CYMiddlesex University · GBUniversity College London · GBUniversity Hospital Schleswig-Holstein · DEUniversity of Cyprus · CYUniversity of Geneva · CHUniversity of Oulu · FIUniversity of Rostock · DE

Funding

European Union's Horizon 2020 research and innovation programme 668259
6 · The paper itself

Abstract

Endotracheal suctioning is a widely used procedure to remove secretions from the airways of ventilated patients. Despite its prevalence, regional effects of this maneuver have seldom been studied. In this study, we explore its effects on regional lung aeration in neonates and young infants using electrical impedance tomography (EIT) as part of the large EU-funded multicenter observational study CRADL. 200 neonates and young infants in intensive care units were monitored with EIT for up to 72 h. EIT parameters were calculated to detect changes in ventilation distribution, ventilation inhomogeneity and ventilation quantity on a breath-by-breath level 5-10 min before and after suctioning. The intratidal change in aeration over time was investigated by means of regional expiratory time constants calculated from all respiratory cycles using an innovative procedure and visualized by 2D maps of the thoracic cross-section. 344 tracheal suctioning events from 51 patients could be analyzed. They showed no or very small changes of EIT parameters, with a dorsal shift of the center of ventilation by 0.5% of the chest diameter and a 7% decrease of tidal impedance variation after suctioning. Regional time constants did not change significantly. Routine suctioning led to EIT-detectable but merely small changes of the ventilation distribution in this study population. While still a measure requiring further study, the time constant maps may help clinicians interpret ventilation mechanics in specific cases.

Indexed as

Critical IllnessTomographyElectric ImpedanceHumansInfantInfant, NewbornLungSuction

Identifiers

PMID38012186
PMCPMC10682352
OpenAlexW4389058622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.