Observational studyESC heart failure2024
Differential effect of left ventricular unloading according to the aetiology of cardiogenic shock.
Observational study in ESC heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Mechanical Support in Myocardial Infarction Complicated by Cardiogenic Shock: What Have We Learned from Trials?Journal of clinical medicine · 2026Review
- Special topics: heart failure-related cardiogenic shock, valvular heart disease and end-stage renal disease. Part 4 of the International Expert Opinion Series on Acute Heart Failure Management.Heart failure reviews · 2025Review
- Extracorporeal Life Support in a Porcine Model of Septic Endotoxemia with Acute Pulmonary Hypertension: An Experimental Study.Journal of clinical medicine · 2025Article
- Variability in triggers for mechanical left ventricular unloading in VA-ECMO: A literature search.The journal of extra-corporeal technology · 2025Review
- Venoarterial Membrane Oxygenation in Cardiogenic Shock Complicated from an Acute Myocardial Infarction: An Overview and Comprehensive Meta-Analysis.Biomedicines · 2025Article
- Left ventricle unloading during veno-arterial extracorporeal membrane oxygenation: review with updated evidence.Acute and critical care · 2024Article
- Different strategies in left ventricle unloading during venoarterial extracorporeal membrane oxygenation: A network meta-analysis.International journal of cardiology. Heart & vasculature · 2024Review
- Left ventricular unloading and venting in veno-arterial extracorporeal membrane oxygenation: the importance of cardiogenic shock aetiology in guiding treatment strategies.ESC heart failure · 2024Article
- Differential effect of left ventricular unloading according to the aetiology of cardiogenic shock.ESC heart failure · 2024Observational
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsEvidence for the effectiveness of left ventricular (LV) unloading in patients who received venoaterial extracorporeal membrane oxygenation (VA-ECMO) for acute myocardial infarction (AMI) or non-AMI induced cardiogenic shock (CS) is limited. The aim of the present study was to compare the effect of LV unloading in AMI-induced and non-AMI-induced CS. METHODS AND
resultsThis is a single-centre retrospective observational study of patients with CS undergoing VA-ECMO from January 2011 to March 2019. Patients were classified as AMI-induced and non-AMI-induced CS. The association of LV unloading with 90-day mortality in both groups was analysed using Cox proportional hazard regression analysis.
resultsOf the 128 CS patients, 71 (55.5%) patients received VA-ECMO due to AMI-induced CS, and the remaining 57 (44.5%) received VA-ECMO due to non-AMI-induced CS. The modality of LV unloading was predominantly with IABP (94.5%). In the AMI-induced CS group, LV unloading did not reduce 90-day mortality (adjusted hazard ratio 1.96, 95% confidence interval 0.90-4.27, P = 0.089). However, in the non-AMI-induced CS group, LV unloading combined with VA-ECMO significantly reduced 90-day mortality (adjusted hazard ratio 0.37, 95% confidence interval 0.14-0.96, P = 0.041; P for interaction = 0.029) as compared with those who received VA-ECMO alone.
conclusionsLV unloading with VA-ECMO may reduce 90-day mortality compared with VA-ECMO alone in patients with non-AMI-induced CS, but not in AMI-induced CS.
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