Evidence map›Paper›PMID 38012064›Full record

ArticleESC heart failure2024

Use of invasive cardiopulmonary exercise testing to diagnose preload reserve failure in patients with liver disease.

Carolyn G Ahlers, Priyesh Patel, Kishan Parikh, Marat Fudim

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Carolyn G AhlersDepartment of Medicine, Duke University Hospital, Durham, NC, USA.ORCID https://orcid.org/0000-0002-8149-1774
Priyesh PatelAtrium Health Sanger Heart and Vascular Institute, Concord, NC, USA.
Kishan ParikhDepartment of Medicine, Duke University Hospital, Durham, NC, USA.
Marat FudimDepartment of Medicine, Duke University Hospital, Durham, NC, USA.
Atrium Medical Cente · USClinical Research Institute · USDuke University Hospital · USUniversity of Wrocław · PL

Funding

American Heart Association 20IPA35310955
6 · The paper itself

Abstract

In this case series, we describe the use of invasive cardiopulmonary exercise testing (iCPET) to diagnose heart failure due to preload reserve failure in two patients with progressive dyspnoea. We demonstrate that underlying liver disease contributes to preload reserve failure as a cause of exertional dysfunction. In liver diseases such as non-alcoholic fatty liver disease (NAFLD), fibrotic changes to the sinusoidal liver architecture occur leading to an increased transhepatic sinusoidal pressure gradient. Even at the earliest stage of hepatic fibrosis in patients with NAFLD, changes in hepatic blood flow are seen due to outflow block in the sinusoidal area. In this way, changes to the sinusoidal liver architecture can lead to limitations in preload reserve. This case series describes two patients with exertional dyspnoea found to have preload failure on iCPET due to underlying liver disease.

Indexed as

Non-alcoholic Fatty Liver DiseaseDyspneaExercise TestHemodynamicsHumansLiver CirrhosisHeart failureInvasive cardiopulmonary exercise testingNon-alcoholic fatty liver diseasePreload reserve failure

Identifiers

PMID38012064
PMCPMC10804147
OpenAlexW4389068486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.