ReviewPLoS genetics2023
An allele-sharing, moment-based estimator of global, population-specific and population-pair FST under a general model of population structure.
Review in PLoS genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Allelic association analyses: estimation recommendations.Genetics · 2026Article
- Genetically diverse populations hold the keys to climatic adaptation in the Western barn owl (Tyto alba).Communications biology · 2026Article
- Genetic Diversity and Gene Flow of the Ectomycorrhizal MushroomJournal of fungi (Basel, Switzerland) · 2026Article
- Contrasting patterns of population structure in two habitat-forming kelp species in southeastern Australia.Journal of phycology · 2026Article
- A method for identifying local adaptation in structured populations.PLoS genetics · 2025Article
- Error rates in QST-FST comparisons depend on genetic architecture and estimation procedures.Genetics · 2025Article
- Error rates inbioRxiv : the preprint server for biology · 2024Article
- Correction: An allele-sharing, moment-based estimator of global, population-specific and population-pair FST under a general model of population structure.PLoS genetics · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
Being able to properly quantify genetic differentiation is key to understanding the evolutionary potential of a species. One central parameter in this context is FST, the mean coancestry within populations relative to the mean coancestry between populations. Researchers have been estimating FST globally or between pairs of populations for a long time. More recently, it has been proposed to estimate population-specific FST values, and population-pair mean relative coancestry. Here, we review the several definitions and estimation methods of FST, and stress that they provide values relative to a reference population. We show the good statistical properties of an allele-sharing, method of moments based estimator of FST (global, population-specific and population-pair) under a very general model of population structure. We point to the limitation of existing likelihood and Bayesian estimators when the populations are not independent. Last, we show that recent attempts to estimate absolute, rather than relative, mean coancestry fail to do so.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.