Evidence map›Paper›PMID 38011279›Full record

ArticlePLoS neglected tropical diseases2023

Central nervous system infection in a pediatric population in West Java.

Dewi H Alisjahbana, Syndi Nurmawati, Mia Milanti, Hofiya Djauhari, Jeremy P Ledermann, Ungke Antonjaya, Yora Permata Dewi, Edison Johar, Ageng Wiyatno, Ida Yus Sriyani and 5 more

Open access · goldAbstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. IDCases · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Dewi H AlisjahbanaDepartment of Child Health, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Syndi NurmawatiResearch Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia.
Mia MilantiDepartment of Child Health, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Hofiya DjauhariResearch Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia.
Jeremy P LedermannCenters for Disease Control and Prevention, Fort Collins, Colorado, United States of America.
Ungke AntonjayaOxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Yora Permata DewiEmerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
Edison JoharEmerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
Ageng WiyatnoEmerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
Ida Yus SriyaniEmerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
Bachti AlisjahbanaResearch Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia.
Dodi SafariEijkman Research Center for Molecular Biology, National Research and Innovation Agency, Jakarta, Indonesia.
Khin Saw Aye MyintEmerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia.ORCID 0000-0002-2087-7331
Ann M PowersCenters for Disease Control and Prevention, Fort Collins, Colorado, United States of America.
Dzulfikar Dl HakimDepartment of Child Health, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Eijkman Institute for Molecular Biology · IDDr. Hasan Sadikin General Hospital · IDCenters for Disease Control and Prevention · USPadjadjaran University · ID

Funding

NCEZID CDC HHS U01 CK000577
6 · The paper itself

Abstract

Central nervous system (CNS) viral infections are critical causes of morbidity and mortality in children; however, comprehensive data on etiology is lacking in developing countries such as Indonesia. To study the etiology of CNS infections in a pediatric population, 50 children admitted to two hospitals in Bandung, West Java, during 2017-2018 were enrolled in a CNS infection study. Cerebrospinal fluid and serum specimens were tested using molecular, serological, and virus isolation platforms for a number of viral and bacteriological agents. Causal pathogens were identified in 10 out of 50 (20%) and included cytomegalovirus (n = 4), Streptococcus pneumoniae (n = 2), tuberculosis (n = 2), Salmonella serotype Typhi (n = 1) and dengue virus (n = 1). Our study highlights the importance of using a wide range of molecular and serological detection methods to identify CNS pathogens, as well as the challenges of establishing the etiology of CNS infections in pediatric populations of countries with limited laboratory capacity.

Indexed as

Central Nervous System InfectionsCentral Nervous System Viral DiseasesTuberculosisVirusesChildHumansIndonesia

Identifiers

PMID38011279
PMCPMC10703213
OpenAlexW4389042292

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.