Evidence map›Paper›PMID 38011195›Full record

ArticlePloS one2023

Health status outcome among cannabis addicts after treatment of addiction.

Mohammed Ali A L Siwar, Sayed Hossam El-Din Mansour, Maha A Aldubayan, Ahmad H Alhowail, Yasser S Almogbel, Ashraf Mahmoud Emara

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Substance misuse disorder in Saudi Arabia: A comprehensive examination of current demographic patterns, trends, and intervention requirements.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Mohammed Ali A L SiwarDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Qassim, Saudi Arabia.
Sayed Hossam El-Din MansourPsychiatry Department, Al Amal Hospital for Mental Health, Asir Region, Saudi Arabia.
Maha A AldubayanDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Qassim, Saudi Arabia.
Ahmad H AlhowailDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Qassim, Saudi Arabia.
Yasser S AlmogbelDepartment of Pharmacy Practice, College of Pharmacy, Qassim University, Buraydah, Saudi Arabia.
Ashraf Mahmoud EmaraDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Qassim, Saudi Arabia.ORCID 0000-0002-1114-7580
Qassim University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The abuse of Cannabis is a widespread issue in the Asir region. It has a lot of legal and occupational repercussions. The purpose of this study was to evaluate the health status of cannabis addicts at admission and after treatment using body mass index, glycemic status, liver function, renal function, and oxidative stress. A cross-sectional study was conducted with 120 participants. The study was conducted at Al Amal Hospital for Mental Health in Asir region of Saudi Arabia, with 100 hospitalized patients receiving addiction treatment and 20 healthy volunteers. The participants were divided into two groups: group I, the control group, and group II, the cannabis addicts. The socio-demographic data were gathered. The level of cannabis in the urine and the CWAS [Cannabis Withdrawal Assessment Scale] were determined. In addition, the Body Mass Index [BMI], vital signs [temperature, heart rate, systolic blood pressure, diastolic blood pressure, and respiratory rate], serum levels of albumin, total bilirubin, direct bilirubin, AST, ALT, and ALP, urea, creatinine, Thiobarbituric acid-reactive substances [TBARS], superoxide dismutase [SOD], reduced glutathione [GSH], and catalase [CAT] were analyzed on the first day of admission and after treatment. According to the results, there was no significant change in the body mass index. The vital signs in the cannabis user group were significantly lower than the corresponding admission values. Regarding renal function tests such as urea and creatinine, we found that after treatment, the mean urea and creatinine values in the cannabis user group did not differ significantly from the corresponding admission values. However, after treatment, the mean values of fasting blood glucose levels in the cannabis user group were significantly lower than at admission. Also, the mean values of liver function tests such as albumin, total bilirubin, direct bilirubin, AST, ALT, and ALP in the cannabis user group were significantly lower than the corresponding admission values after treatment. In assessing the antioxidant system, we found that the mean values of TBARS, SOD, GSH, and CAT in the cannabis user group did not differ significantly from the corresponding admission values after treatment. The current findings have revealed that cannabis addiction harms the various body systems and has significant implications for the addict's state of health. The values of oxidative stress biomarkers did not change in this study, but other measured parameters improved after treatment.

Indexed as

CannabisAlbuminsAntioxidantsBilirubinCatalaseCreatinineCross-Sectional StudiesGlutathioneHealth StatusHumansLiverOxidative StressSuperoxide DismutaseThiobarbituric Acid Reactive SubstancesUreaAlbuminsAntioxidantsBilirubinCatalaseCreatinineGlutathioneSuperoxide DismutaseThiobarbituric Acid Reactive SubstancesUrea

Identifiers

PMID38011195
PMCPMC10681311
OpenAlexW4389042765

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.