Evidence map›Paper›PMID 38010871›Full record

ArticleGut microbes2023

Alterations in gut virome are associated with cognitive function and minimal hepatic encephalopathy cross-sectionally and longitudinally in cirrhosis.

Thananya Jinato, Masoumeh Sikaroodi, Andrew Fagan, Richard K Sterling, Hannah Lee, Puneet Puri, Brian C Davis, Michael Fuchs, Edith Gavis, Patrick M Gillevet and 1 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. JHEP reports : innovation in hepatology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Thananya JinatoMicrobiome Analysis Center, George Mason University, Manassas, VA, USA.
Masoumeh SikaroodiMicrobiome Analysis Center, George Mason University, Manassas, VA, USA.
Andrew FaganDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA.
Richard K SterlingDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA.
Hannah LeeDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA.
Puneet PuriDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA.
Brian C DavisDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA.
Michael FuchsDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA.
Edith GavisDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA.
Patrick M GillevetMicrobiome Analysis Center, George Mason University, Manassas, VA, USA.
Jasmohan S BajajDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA.ORCID 0000-0003-4928-3681
Hunter Holmes McGuire VA Medical Center · USGeorge Mason University · USChulalongkorn University · TH

Funding

Fecal microbiota transplant for Alcohol-Associated CirrhosisR01AA029398 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Jasmohan S Bajaj, ALEXANDER KHORUTS · 2022 to 2026
$2.9M
Fecal Microbiota Transplant in Veterans with CirrhosisI01CX001076 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI BAJAJ, JASMOHAN S · 2015 to 2024
–
BCCMA: Targeting Gut Microbiome in Gastrointestinal and Liver Diseases in US Veterans; CMA4: At the Crossroads of the Gut Microbiome, Cirrhosis, and PTSDI01CX002472 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI Jasmohan S Bajaj · 2023 to 2026
–
CSRD VA I01 CX001076CSRD VA I01 CX002472NIAAA NIH HHS R01 AA029398
6 · The paper itself

Abstract

Cognitive dysfunction due to minimal hepatic encephalopathy (MHE) adversely impacts patients with cirrhosis and more precise therapies are needed. Gut-brain axis changes are therapeutic targets, but prior studies have largely focused on bacterial changes. Our aim was to determine linkages between individual cognitive testing results and bacteria with the virome using a cross-sectional and longitudinal approach. We included cross-sectional (

Indexed as

Gastrointestinal MicrobiomeHepatic EncephalopathyCognitionCross-Sectional StudiesFibrosisHumansLiver CirrhosisViromeEncephalApp StroopGut-brain axishepatic encephalopathyinhibitory control testmicrobiomepsychometric hepatic encephalopathy score

Identifiers

PMID38010871
PMCPMC10730154
OpenAlexW4389043375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.