Evidence map›Paper›PMID 38010861›Full record

ArticleThe Kaohsiung journal of medical sciences2024

Curcumin suppresses the Wnt/β-catenin signaling pathway by inhibiting NKD2 methylation to ameliorate intestinal ischemia/reperfusion injury.

Jia-Xi Zhu, Yu Dun, Wei Wu, Jie Shen, Feng Zhang, Lin Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Curcumin in ischemia-reperfusion injury across multiple organs: A review.The Journal of international medical research · 2026
    Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jia-Xi ZhuCenter of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0003-0127-9584
Yu DunCenter of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, China.
Wei WuDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Jie ShenCenter of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, China.
Feng ZhangCenter of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, China.
Lin ZhangCenter of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, China.
Fudan University · CNSun Yat-sen University · CN

Funding

Research Grant for the National Natural Science Foundation of China 81801943Research Project of Shanghai Municipal Health Commission 202040173Research Project of Shanghai Municipal Health Commission 202340280Science and Technology Commission of Shanghai Municipality 18411970200Shanghai Pujiang Program 21PJD009
6 · The paper itself

Abstract

Intestinal ischemia/reperfusion (I/R) injury is a life-threatening condition with no effective treatment currently available. Curcumin (CCM), a polyphenol compound in Curcuma Longa, reportedly has positive effects against intestinal I/R injury. However, the mechanism underlying the protective effect of CCM against intestinal I/R injury has not been fully clarified. To determine whether the protective effect of CCM was mediated by epigenetic effects on Wnt/β-catenin signaling, the effect of CCM was examined in vivo and in vitro. An intestinal I/R model was established in Sprague-Dawley (SD) rats with superior mesenteric artery occlusion, and Caco-2 cells were subjected to hypoxia/reoxygenation (H/R) for in vivo simulation of I/R. The results showed that CCM significantly reduced inflammatory, cell apoptosis, and oxidative stress induced by I/R insult in vivo and in vitro. Western blot analysis showed that CCM preconditioning reduced the protein levels of β-catenin, p-GSK3β, and cyclin-D1 and increased the protein level of GSK3β compared with the I/R group. Overexpressing β-catenin aggravated H/R injury, and knocking down β-catenin relieved H/R injury by improving intestinal permeability and reducing the cell apoptosis. Moreover, Naked cuticle homolog 2(NKD2) mRNA and protein levels were upregulated in the CCM-pretreated group. 5-aza-2'-deoxycytidine (5-AZA) treatment improved intestinal epithelial barrier impairment induced by H/R. Besides, the protein levels of total β-catenin, phosphor-β-catenin and cyclin-D1 were reduced after overexpressing NKD2 in Caco-2 cells following H/R insult. In conclusion, Our study suggests that CCM could attenuate intestinal I/R injury in vitro and in vivo by suppressing the Wnt/β-catenin signaling pathway via inhibition of NKD2 methylation.

Indexed as

CurcuminReperfusion InjuryAdaptor Proteins, Signal TransducingAnimalsApoptosisbeta CateninCaco-2 CellsCalcium-Binding ProteinsCyclinsGlycogen Synthase Kinase 3 betaHumansIschemiaMethylationRatsRats, Sprague-DawleyWnt Signaling PathwayAdaptor Proteins, Signal Transducingbeta CateninCalcium-Binding ProteinsCurcuminCyclinsGlycogen Synthase Kinase 3 betaNKD2 protein, humancurcuminDNA methylationintestinal ischemia/reperfusion (I/R) injurynaked cuticle homolog 2 (NKD2)Wnt/β-catenin signaling pathway

Identifiers

PMID38010861
PMCPMC11895583
OpenAlexW4389070691

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.