Evidence map›Paper›PMID 38010793›Full record

ArticleGut microbes2023

Multi-omics analyses demonstrate the modulating role of gut microbiota on the associations of unbalanced dietary intake with gastrointestinal symptoms in children with autism spectrum disorder.

Hailin Li, Churui Liu, Saijun Huang, Xin Wang, Muqing Cao, Tingfeng Gu, Xiaoxuan Ou, Shuolin Pan, Zongyu Lin, Xiaotong Wang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Hailin LiDepartment of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Churui LiuSchool of Biological Engineering, Dalian Polytechnic University, Dalian, Liaoning, China.
Saijun HuangDepartment of Child Healthcare, Affiliated Foshan Maternity and Child Healthcare Hospital, Southern Medical University, Foshan, Guangdong, China.
Xin WangKey Laboratory of Brain, Cognition and Education Science, Ministry of Education, Institute for Brain Research and Rehabilitation, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, Guangdong, China.
Muqing CaoDepartment of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Tingfeng GuDepartment of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Xiaoxuan OuDepartment of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Shuolin PanDepartment of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Zongyu LinDepartment of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Xiaotong WangDepartment of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yanna ZhuDepartment of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Jin JingDepartment of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Sun Yat-sen University · CNDalian Polytechnic University · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous work revealed that unbalanced dietary intake was an important independent factor associated with constipation and gastrointestinal (GI) symptoms in children with autism spectrum disorder (ASD). Growing evidence has shown the alterations in the gut microbiota and gut microbiota-derived metabolites in ASD. However, how the altered microbiota might affect the associations between unbalanced diets and GI symptoms in ASD remains unknown. We analyzed microbiome and metabolomics data in 90 ASD and 90 typically developing (TD) children based on 16S rRNA and untargeted metabolomics, together with dietary intake and GI symptoms assessment. We found that there existed 11 altered gut microbiota (FDR-corrected P-value <0.05) and 397 altered metabolites (P-value <0.05) in children with ASD compared with TD children. Among the 11 altered microbiota, the

Indexed as

Autism Spectrum DisorderGastrointestinal DiseasesGastrointestinal MicrobiomeChildConstipationEatingHumansMultiomicsRNA, Ribosomal, 16SRNA, Ribosomal, 16Sautism spectrum disordergastrointestinal symptomsgut microbiotametabolomicsUnbalanced dietary intake

Identifiers

PMID38010793
PMCPMC10730204
OpenAlexW4389045004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.