Evidence map›Paper›PMID 38010414›Full record

ArticleCellular and molecular life sciences : CMLS2023

Molecular modeling of apoE in complexes with Alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids.

Emily Lewkowicz, Mari N Nakamura, Michael J Rynkiewicz, Olga Gursky

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Apolipoprotein E Gene in α-Synucleinopathies: A Narrative Review.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Emily LewkowiczDepartment of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, W302, 700 Albany Street, Boston, MA, 02118, USA.ORCID http://orcid.org/0000-0002-9551-536X
Mari N NakamuraUndergraduate program, Department of Chemistry and Biochemistry, Middlebury College, 14 Old Chapel Rd, Middlebury, VT, 05753, USA.
Michael J RynkiewiczDepartment of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, W302, 700 Albany Street, Boston, MA, 02118, USA.ORCID http://orcid.org/0000-0002-4717-5700
Olga GurskyDepartment of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, W302, 700 Albany Street, Boston, MA, 02118, USA. gursky@bu.edu.ORCID http://orcid.org/0000-0002-8598-4824
Boston University · USMiddlebury College · US

Funding

Structural Thermodynamics of Human Apolipoprotein C-1R01GM067260 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GURSKY, OLGA · 2003 to 2024
$7.4M
THIN FILAMENTS AND VERTEBRATE SMOOTH MUSCLE CONTRACTIONR01HL036153 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI William J Lehman · 1986 to 2026
$6.5M
TRAINING PROGRAM IN ENDOCRINE AND METABOLIC RESEARCHT32DK007201 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CORKEY, BARBARA E., KANDROR, KONSTANTIN V · 1986 to 2023
$6.4M
Thin Filaments and Muscle RegulationR37HL036153 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LEHMAN, WILLIAM J · 2008 to 2017
$4.1M
Structure and Function of Serum Amyloid A in Health and DiseaseR01GM135158 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Olga Gursky · 2020 to 2026
$2.4M
THIN FILAMENTS AND VERTEBRATE SMOOTH MUSCLE CONTRACTIONR55HL036153 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LEHMAN, WILLIAM J · 1992 to 1992
–
NHLBI NIH HHS HL036153.NHLBI NIH HHS R01 HL036153NHLBI NIH HHS R37 HL036153NIDDK NIH HHS 5T32DK007201-43NIDDK NIH HHS T32 DK007201NIGMS NIH HHS GM067260NIGMS NIH HHS GM135158NIGMS NIH HHS R01 GM067260NIGMS NIH HHS R01 GM135158
6 · The paper itself

Abstract

Apolipoproteins co-deposit with amyloids, yet apolipoprotein-amyloid interactions are enigmatic. To understand how apoE interacts with Alzheimer's amyloid-β (Aβ) peptide in fibrillary deposits, the NMR structure of full-length human apoE was docked to four structures of patient-derived Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesApolipoproteins EAmyloidApolipoproteinsBrainCryoelectron MicroscopyHumansMolecular Dynamics SimulationPeptide FragmentsAmyloidAmyloid beta-PeptidesApolipoproteinsApolipoproteins EPeptide FragmentsAmphipathic apolipoprotein α-helicesAmyloid signature proteinsAtomic structuresCryptic binding sitesExposed hydrophobic surfacesFibril polymorphs

Identifiers

PMID38010414
PMCPMC11061799
OpenAlexW4389048792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.