Evidence map›Paper›PMID 38010399›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2024

Procyanidin alleviates ferroptosis and inflammation of LPS-induced RAW264.7 cell via the Nrf2/HO-1 pathway.

Jiayan Zeng, Yanmin Weng, Tianli Lai, Lan Chen, Ying Li, Qiqi Huang, Saiyi Zhong, Shibiao Wan, Lianxiang Luo

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jiayan Zeng *The First Clinical College, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Yanmin Weng *The First Clinical College, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Tianli Lai *The First Clinical College, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Lan ChenThe First Clinical College, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Ying LiThe First Clinical College, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Qiqi HuangThe First Clinical College, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Saiyi ZhongGuangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, 524088, China.
Shibiao WanDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA. swan@unmc.edu.
Lianxiang LuoThe Marine Biomedical Research Institute, Guangdong Medical University, No. 2 Wenming East Road, Xiashan District, Zhanjiang, 524023, Guangdong, China. luolianxiang321@gdmu.edu.cn.
Guangdong Medical College · CNGuangdong Ocean University · CNUniversity of Nebraska Medical Center · US

Funding

Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety (GDPLLAPPS2104)The Guangdong Provincial Department of Education Research Project (2022KTSCX)the Science and Technology Special Project of Zhanjiang (2022A01034)
6 · The paper itself

Abstract

Inflammation is a common occurrence in many medical conditions and is a natural defense mechanism of the human body. Ferroptosis, an iron-dependent form of cell death related to lipid peroxide build-up, has been found to be involved in inflammation. The anti-inflammatory effects of procyanidin, however, are not yet fully understood. Through network pharmacology and bioinformatics analysis, it was suggested that procyanidin could modulate ferroptosis and cause anti-inflammatory effects on RAW264.7 cells. This was further evidenced through molecular docking, molecular dynamics, and in vitro experiments. The results indicated that procyanidin could diminish inflammation in LPS-induced RAW264.7 cells by regulating ferroptosis via the Nrf2/HO-1/Keap-1 pathway. In conclusion, procyanidin supplementation might be an effective way to reduce inflammation by decreasing the release of inflammatory cytokines and suppressing ferroptosis.

Indexed as

Anti-Inflammatory AgentsBiflavonoidsCatechinFerroptosisInflammationLipopolysaccharidesNF-E2-Related Factor 2ProanthocyanidinsAnimalsHeme Oxygenase-1Heme Oxygenase (Decyclizing)Kelch-Like ECH-Associated Protein 1Membrane ProteinsMiceMolecular Docking SimulationNetwork PharmacologyAnti-Inflammatory AgentsBiflavonoidsCatechinHeme Oxygenase-1Heme Oxygenase (Decyclizing)Hmox1 protein, mouseKeap1 protein, mouseKelch-Like ECH-Associated Protein 1LipopolysaccharidesMembrane ProteinsNfe2l2 protein, mouseNF-E2-Related Factor 2ProanthocyanidinsprocyanidinFerroptosisInflammationNrf2/HO-1/Keap-1 pathwayProcyanidin

Identifiers

PMID38010399
OpenAlexW4389049654

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.