Evidence map›Paper›PMID 38010398›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2024

Antitumor effect of tubeimoside-I on murine colorectal cancers through PKM2-dependent pyroptosis and immunomodulation.

Dongsheng Hu, Lingzhi Cui, Sijia Zhang, Siqi He, Yuzhen Zhuo, Dihua Li, Lanqiu Zhang, Yanli Wang, Lei Yang, Ximo Wang

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Dongsheng HuGraduate School, Tianjin Medical University, Tianjin, China.
Lingzhi CuiGraduate School, Tianjin Medical University, Tianjin, China.
Sijia ZhangGraduate School, Tianjin Medical University, Tianjin, China.
Siqi HeGraduate School, Tianjin Medical University, Tianjin, China.
Yuzhen ZhuoTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin Nankai Hospital, Tianjin, China.
Dihua LiTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin Nankai Hospital, Tianjin, China.
Lanqiu ZhangTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin Nankai Hospital, Tianjin, China.
Yanli WangTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin Nankai Hospital, Tianjin, China.
Lei YangTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin Nankai Hospital, Tianjin, China. nkyanglei@126.com.
Ximo WangGraduate School, Tianjin Medical University, Tianjin, China. wangximonkyy@126.com.
Tianjin Nankai Hospital · CNTianjin Medical University · CNTianjin University · CN

Funding

National Natural Science Foundation of China 81971858Natural Science Foundation of Inner Mongolia 2022MS08029Natural Science Foundation of Tianjin City 18JCQNJC13400Natural Science Foundation of Tianjin City 19JCZDJC36200Tianjin Municipal Bureau of Public Health 2021009Tianjin Municipal Bureau of Public Health 2021044Tianjin Municipal Bureau of Public Health 2021097
6 · The paper itself

Abstract

Induction of cancer cell death is an established treatment strategy, but chemotherapy drug-mediated apoptosis can be evaded by many tumors. Pyroptosis is a type of inflammatory programmed cell death (PCD) that is important for organism immunity. Tubeimoside-I (TBMS1) is a plant-derived component that exhibits antitumor activity. However, it is unclear how TBMS1 induces pyroptosis to inhibit colorectal cancer (CRC). In this study, we demonstrated that TBMS1 is able to induce pyroptosis in murine CRC cells and releases pro-inflammatory cytokines. Mechanistically, we found that TBMS1 inhibits CRC cell proliferation and migration and induces pyroptosis by activating caspase-3 and cleaving gasdermin E (GSDME) through the inhibition of PKM2. In the animal experiments, TBMS1 attenuated the weight of solid tumors, increased the proportion of CD8

Indexed as

Cell ProliferationColorectal NeoplasmsMembrane ProteinsPhosphate-Binding ProteinsPyroptosisSaponinsThyroid Hormone-Binding ProteinsTriterpenesAnimalsAntineoplastic AgentsCarrier ProteinsCaspase 3Cell Line, TumorCell MovementCytokinesGasderminsAntineoplastic AgentsCarrier ProteinsCasp3 protein, mouseCaspase 3CytokinesGasderminsGsdme protein, mouseMembrane ProteinsPhosphate-Binding ProteinsPkm protein, mousePyruvate KinaseSaponinsThyroid Hormone-Binding ProteinsThyroid HormonesTriterpenestubeimoside IAntitumor immunityGasdermin EPyroptosisPyruvate kinase M2Tubeimoside-I

Identifiers

PMID38010398
OpenAlexW4389049683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.