Evidence map›Paper›PMID 38010367›Full record

ArticleJournal of biophotonics2024

Femtosecond optical Kerr effect in normal and grades of cancerous breast tissues as a new optical biopsy method.

Henry J Meyer, Sandra Mamani, Zhi Li, Lingyan Shi, Robert R Alfano

Abstract read
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In one paragraph

Article in Journal of biophotonics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Henry J MeyerDepartment of Physics and Electrical Engineering, Institute for Ultrafast Spectroscopy and Lasers, The City College of the City University of New York, New York, New York, USA.
Sandra MamaniDepartment of Physics and Electrical Engineering, Institute for Ultrafast Spectroscopy and Lasers, The City College of the City University of New York, New York, New York, USA.
Zhi LiShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, San Diego, USA.
Lingyan ShiShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, San Diego, USA.
Robert R AlfanoDepartment of Physics and Electrical Engineering, Institute for Ultrafast Spectroscopy and Lasers, The City College of the City University of New York, New York, New York, USA.
City University of New York · USUniversity of California, San Diego · USCity College of New York · US

Funding

Training and Career Development and Education CoreU54CA137788 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ADRIANA ESPINOSA, FRANCESCA M GANY · 2008 to 2026
$28.1M
Novel Optical Imaging Approach to Study Neurovascular Coupling SystemR21NS125395 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHI, LINGYAN · 2022 to 2022
$435k
NIH HHS CA137788NIH HHS CM0004266-00NIH HHS U54NINDS NIH HHS R21 NS125395
6 · The paper itself

Abstract

This study reports on the first use of the optical Kerr effect (OKE) in breast cancer tissue. This proposed optical biopsy method utilizes a Femtosecond Optical Kerr Gate to detect changes in dielectric relaxation and conductivity created by a cancerous infection. Here, the temporal behavior of the OKE is tracked in normal and cancerous samples of human and mouse breast. These tissues display a double peaked temporal structure and its decay rate changes depending on the tissue's infection status. The decay of the secondary peak, attributed to ultrafast plasma response, indicates that the tissue's conductivity has doubled once infected. A slower molecular contribution to the Kerr effect can also be observed in healthy tissues. These findings suggest two possible biomarkers for the use of OKE in optical biopsy. Both markers arise from alterations in the infected tissue's cellular structure, which changes the rate at which electronic and molecular processes occur.

Indexed as

Breast NeoplasmsAnimalsBiopsyFemaleHumansMicecancerdetectionelectronic processesKerr effectoptical biopsytime resolvedtissuesultrafast

Identifiers

PMID38010367
OpenAlexW4389069595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.