ArticleThe Journal of cell biology2024
The dynamic recruitment of LAB proteins senses meiotic chromosome axis differentiation in C. elegans.
Article in The Journal of cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Chromosome movements in meiotic prophase: regulatory mechanisms and biological roles.Frontiers in cell and developmental biology · 2026Review
- Chromatin remodeler ISW-1 orchestrates chromosome axis assembly and meiotic progression in C. elegans.Nucleic acids research · 2025Article
- A DNA-containing phase-separated compartment links the nuclear envelope to chromosome axes to promote homolog pairing inScience advances · 2025Article
- Cohesin ring gates are specialized for meiotic cell division.Journal of molecular cell biology · 2025Article
- Identification of the Polo-like kinase substrate required for homologous synapsis.The Journal of cell biology · 2025Article
- A chromosome-coupled ubiquitin-proteasome pathway is required for meiotic surveillance.Cell death and differentiation · 2024Article
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Authors and funding
12 authors.
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Abstract
During meiosis, cohesin and meiosis-specific proteins organize chromatin into an axis-loop architecture, coordinating homologous synapsis, recombination, and ordered chromosome segregation. However, how the meiotic chromosome axis is assembled and differentiated with meiotic progression remains elusive. Here, we explore the dynamic recruitment of two long arms of the bivalent proteins, LAB-1 and LAB-2, in Caenorhabditis elegans. LAB proteins directly interact with the axis core HORMA complexes and weak interactions contribute to their recruitment. LAB proteins phase separate in vitro, and this capacity is promoted by HORMA complexes. During early prophase, synapsis oppositely regulates the axis enrichment of LAB proteins. After the pachytene exit, LAB proteins switch from a reciprocal localization pattern to a colocalization pattern, and the normal dynamic pattern of LAB proteins is altered in meiotic mutants. We propose that LAB recruitment senses axis differentiation, and phase separation of meiotic structures helps subdomain establishment and accurate segregation of the chromosomes.
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