Trial reportMicrobiology spectrum2024
COVID-19 convalescent plasma therapy decreases inflammatory cytokines: a randomized controlled trial.
Open access · goldAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- COVID-19 convalescent plasma safety and efficacy analysis for biologics license application approval.Expert review of anti-infective therapy · 2026Review
- A Surrogate Enzyme-Linked Immunosorbent Assay to Select High-Titer Human Convalescent Plasma for Treating Immunocompromised Patients Infected With Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern.The Journal of infectious diseases · 2025Article
- Estimates of actual and potential lives saved in the United States from the use of COVID-19 convalescent plasma.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors at 20 institutions in 1 country.
Feben Habtehyimer *Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.ORCID 0009-0006-2992-0822
Xianming Zhu *Department of Pathology, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.ORCID 0000-0002-3317-7449
Andrew D ReddDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.ORCID 0000-0003-4651-1423
Kelly A GeboDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
Alison G AbrahamDepartment of Epidemiology, University of Colorado, Anschutz Medical Campus , Aurora, Colorado, USA.
Eshan U PatelDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.ORCID 0000-0003-2174-5004
Oliver LaeyendeckerDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Baltimore, Maryland, USA.ORCID 0000-0002-6429-4760
Thomas J GniadekDepartment of Pathology and Laboratory Medicine, Northshore University Health System , Evanston, Illinois, USA.
Reinaldo E FernandezDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
Owen R BakerDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
Malathi RamDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.
Edward R CachayDepartment of Medicine, Division of Infectious Diseases, University of California, San Diego , San Diego, California, USA.
Judith S CurrierDepartment of Medicine, Division of Infectious Diseases, University of California, Los Angeles , Los Angeles, California, USA.
Yuriko FukutaDepartment of Medicine, Section of Infectious Diseases, Baylor College of Medicine , Houston, Texas, USA.
Jonathan M GerberDepartment of Medicine, Division of Hematology and Oncology, University of Massachusetts Chan Medical School , Worcester, Massachusetts, USA.
Sonya L HeathDepartment of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham , Birmingham, Alabama, USA.
Barry MeisenbergDepartment of Medicine and Research Institute of Luminis Health , Annapolis, Maryland, USA.
Moises A HuamanDepartment of Medicine, Division of Infectious Diseases, University of Cincinnati , Cincinnati, Ohio, USA.
Adam C LevineDepartment of Emergency Medicine, Warren Alpert Medical School of Brown University , Providence, Rhode Island, USA.
Aarthi ShenoyDepartment of Medicine, Division of Hematology and Oncology, MedStar Washington Hospital Center , Washington, DC, USA.
Shweta AnjanDepartment of Medicine, Division of Infectious Diseases, University of Miami, Miller School of Medicine , Miami, Florida, USA.
Janis E BlairDepartment of Medicine, Division of Infectious Diseases, Mayo Clinic Hospital , Phoenix, Arizona, USA.
Daniel CruserDepartment of Pathology, Nuvance Health Vassar Brothers Medical Center , Poughkeepsie, New York, USA.
Donald N ForthalDepartment of Medicine, Division of Infectious Diseases, University of California, Irvine , Irvine, California, USA.ORCID 0000-0001-6687-6775
Laura L HammittDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.
Seble KassayeDivision of Infectious Diseases, Georgetown University Medical Center , Washington, DC, USA.
Giselle S MosnaimDepartment of Medicine, Division of Allergy and Immunology, Northshore University Health System , Evanston, Illinois, USA.
Bela PatelDepartment of Medicine, Divisions of Pulmonary and Critical Care Medicine, University of Texas Health Science Center , Houston, Texas, USA.
James H PaxtonDepartment of Emergency Medicine, Wayne State University , Detroit, Michigan, USA.
Jay S RavalDepartment of Pathology, University of New Mexico , Albuquerque, New Mexico, USA.
Catherine G SutcliffeDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.ORCID 0000-0001-8512-8326
Matthew AbinanteAscada Research , Fullerton, California, USA.
Kevin S OeiAscada Research , Fullerton, California, USA.
Valerie CluzetDepartment of Infectious Disease, Nuvance Health Vassar Brothers Medical Center , Poughkeepsie, New York, USA.
Marie Elena CordiscoNuvance Health Danbury Hospital , Danbury, Connecticut, USA.
Benjamin GreenblattNuvance Health Norwalk Hospital , Norwalk, Connecticut, USA.
William RauschNuvance Health Danbury Hospital , Danbury, Connecticut, USA.
David ShadeDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.
Amy L GawadDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.
Sabra L KleinDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.ORCID 0000-0002-0730-5224
Andrew PekoszDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.ORCID 0000-0003-3248-1761
Shmuel ShohamDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.ORCID 0000-0002-9402-9167
Evan M BlochDepartment of Pathology, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
Daniel HanleyDepartment of Neurology, Brain Injury Outcomes Division, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
Aaron A R TobianDepartment of Pathology, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.ORCID 0000-0002-0517-3766
David J SullivanDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.ORCID 0000-0003-0319-0578
Johns Hopkins University · USDanbury Hospital · USNational Institutes of Health · USNorthShore University HealthSystem · USVassar Brothers Medical Center · USBaylor College of Medicine · USBrown University · USGeorgetown University · USMayo Clinic Hospital · USMedStar Washington Hospital Center · USNorwalk Hospital · USThe University of Texas Health Science Center at Houston · USUniversity of Alabama at Birmingham · USUniversity of California, Irvine · USUniversity of California, Los Angeles · USUniversity of California San Diego · USUniversity of Cincinnati · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Massachusetts Chan Medical School · USUniversity of Miami · US
Funding
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8MJohns Hopkins-Tufts Trial Innovation Center HEAL Pain ERN SupplementU24TR001609 · NCATS · JOHNS HOPKINS UNIVERSITY · PI HANLEY, DANIEL F · 2016 to 2022
$36.3MUniversity of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1MInternational Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8MConjugate vaccines for prevention and treatment of cryptococcosis - COVID-19 Revision SupplementR01AI152078 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2020 to 2024
$5.1MUnlocking the Potential of HIV-Infected Deceased Donors for Organ TransplantationR01AI120938 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2016 to 2021
$4.3MT-cell depletion and maintenance of the HIV-1 latent reservoir in distinct tissue compartmentsR01DK131926 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Melissa Laird Smith, AARON A TOBIAN · 2022 to 2026
$3.6MThe Malaria Transfusion Risk (MATRix) StudyK23HL151826 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BLOCH, EVAN MARTIN · 2020 to 2024
$882kColliding Epidemics During an Opioid Crisis: Impact of the COVID-19 Pandemic on Determinants of HIV and HCV Transmission Among People Who Inject DrugsF31DA054849 · NIDA · JOHNS HOPKINS UNIVERSITY · PI PATEL, ESHAN UDAY · 2021 to 2023
$140kNCATS NIH HHS U24 TR001609NHLBI NIH HHS K23 HL151826NIAID NIH HHS R01 AI120938NIAID NIH HHS R01 AI152078NIDA NIH HHS F31 DA054849NIDDK NIH HHS R01 DK131926
Abstract
importanceThis study examined the role that cytokines may have played in the beneficial outcomes found when outpatient individuals infected with SARS-CoV-2 were transfused with COVID-19 convalescent plasma (CCP) early in their infection. We found that the pro-inflammatory cytokine IL-6 decreased significantly faster in patients treated early with CCP. Participants with COVID-19 treated with CCP later in the infection did not have the same effect. This decrease in IL-6 levels after early CCP treatment suggests a possible role of inflammation in COVID-19 progression. The evidence of IL-6 involvement brings insight into the possible mechanisms involved in CCP treatment mitigating SARS-CoV-2 severity.
Indexed as
COVID-19COVID-19 SerotherapyCytokinesHumansImmunization, PassiveInterleukin-6SARS-CoV-2CytokinesInterleukin-6chemokinesconvalescent plasmaCOVID-19COVID-19 serotherapycytokinesrandomized trialSARS-CoV-2
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.