Evidence map›Paper›PMID 38009930›Full record

ArticleJournal of virology2023

Linoleic acid: a natural feed compound against porcine epidemic diarrhea disease.

Shanshan Yang, Xin Huang, Shuxian Li, Caiying Wang, Christine A Jansen, Huub F J Savelkoul, Guangliang Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Shanshan YangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, China.ORCID 0009-0000-7748-0223
Xin HuangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, China.
Shuxian LiState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, China.
Caiying WangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, China.
Christine A JansenCell Biology and Immunology Group, Wageningen University and Research, Wageningen, the Netherlands.
Huub F J SavelkoulCell Biology and Immunology Group, Wageningen University and Research, Wageningen, the Netherlands.
Guangliang LiuState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, China.ORCID 0000-0001-8158-5749
Lanzhou Veterinary Research Institute · CNWageningen University & Research · NLXinjiang Agricultural University · CNJiangsu Academy of Agricultural Sciences · CN

Funding

Joint Science Foundation of Gansu Province 23JRRA1516MOST | National Natural Science Foundation of China (NSFC) U22A20522, 31972689Science and Technology Major Project of Gansu Province 22ZD6NA001
6 · The paper itself

Abstract

importancePorcine epidemic diarrhea virus (PEDV) is a pig coronavirus that causes severe diarrhea and high mortality in piglets, but as no effective drugs are available, this virus threatens the pig industry. Here, we found that the intestinal contents of specific pathogen-free pigs effectively blocked PEDV invasion. Through proteomic and metabolic analyses of the intestinal contents, we screened 10 metabolites to investigate their function and found that linoleic acid (LA) significantly inhibited PEDV replication. Further investigations revealed that LA inhibited viral replication and release mainly by binding with PEDV NSP5 to regulate the PI3K pathway and, in particular, inhibiting AKT phosphorylation.

Indexed as

Antiviral AgentsCoronavirus InfectionsDiarrheaLinoleic AcidPorcine epidemic diarrhea virusSwine DiseasesAnimalsPhosphatidylinositol 3-KinasesProteomicsSwineVirus ReplicationAntiviral AgentsLinoleic AcidPhosphatidylinositol 3-KinasesAKTantiviral drugscoronaviruslinoleic acidPEDV

Identifiers

PMID38009930
PMCPMC10734519
OpenAlexW4389036267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.