Evidence map›Paper›PMID 38009843›Full record

ArticleBrain pathology (Zurich, Switzerland)2024

Primary visual cortex pathology in ALS patients with C9ORF72 expansion.

Matthew D Cykowski, Anithachristy S Arumanayagam, Suzanne Z Powell, Stanley H Appel

Abstract readLetter
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The cholinergic basal forebrain and its role in neurodegeneration.Journal of neuropathology and experimental neurology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew D CykowskiDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.ORCID 0000-0002-5973-803X
Anithachristy S ArumanayagamDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Suzanne Z PowellDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Stanley H AppelDepartment of Neurology, Houston Methodist Hospital, Houston, Texas, USA.

Funding

Age-related TDP-43 neuropathology: using disease-driving mechanisms to guide classificationRF1NS118584 · NINDS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CYKOWSKI, MATTHEW DANIEL, NELSON, PETER T. · 2020 to 2020
$3.2M
Age-related TDP-43 neuropathology: using disease-driving mechanisms to guide classificationR01NS118584 · NINDS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CYKOWSKI, MATTHEW DANIEL, NELSON, PETER T. · 2024 to 2024
$791k
ALS Association 19-IIA-465NINDS NIH HHS R01 NS118584NINDS NIH HHS RF1 NS118584NINDS NIH HHS RF1NS118584
6 · The paper itself

Abstract

Poly-GA and poly-GP immunofluorescence studies show conspicuous dipeptide repeat pathology in layers IV and II of primary visual cortex in C9ALS patients.

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinAgedDNA Repeat ExpansionFemaleHumansMaleMiddle AgedPrimary Visual CortexProteinsC9orf72 ProteinC9orf72 protein, humanProteinsALSC9ORF72calcium‐binding proteindipeptide repeatTDP‐43visual cortex

Identifiers

PMID38009843
PMCPMC11328338

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.