Phenotyping of Macrophages After Radiolabeling and Safety of Intra-arterial Transplantation Assessed by SPECT/CT and MRI.

Ida Friberger, Vamsi Gontu, Robert A Harris, Thuy A Tran, Johan Lundberg, Staffan Holmin

Open access · goldAbstract read

In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 54% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ida FribergerDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-6770-7380

Vamsi GontuDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Robert A HarrisDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Thuy A TranDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Johan LundbergDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Staffan HolminDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Karolinska University Hospital · SEKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell therapy is an integral modality of regenerative medicine. Macrophages are known for their sensitivity to activation stimuli and capability to recruit other immune cells to the sites of injury and healing. In addition, the route of administration can impact engraftment and efficacy of cell therapy, and modern neuro-interventional techniques provide the possibility for selective intra-arterial (IA) delivery to the central nervous system (CNS) with very low risk. The effects of radiolabelling and catheter transport on differentially activated macrophages were evaluated. Furthermore, the safety of selective IA administration of these macrophages to the rabbit brain was assessed by single-photon emission computed tomography/computed tomography (SPECT/CT) and ultra-high-field (9.4 T) magnetic resonance imaging (MRI). Cells were successfully labeled with (

Indexed as

Interferon-gammaLipopolysaccharidesAnimalsMacrophagesMagnetic Resonance ImagingRabbitsTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedInterferon-gammaLipopolysaccharidesendovascularintra-arterialMRIrabbitSPECT/CT

Identifiers

PMID38009543

DOI10.1177/09636897231212780

PMCPMC10683405

OpenAlexW4389063358

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.