Evidence map›Paper›PMID 38009421›Full record

ArticleThe FEBS journal2024

NTNH protein: more than a bodyguard for botulinum neurotoxins.

Linfeng Gao, Rongsheng Jin

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. The unsung hero:Frontiers in cellular and infection microbiology · 2026
    Article
  3. Comparative genomics ofMicrobial genomics · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Linfeng GaoDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
Rongsheng JinDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0003-0348-7363
University of California, Irvine · US

Funding

Structure and Function of C. Difficile ToxinsR01AI139087 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Min Dong, Rongsheng Jin · 2018 to 2026
$7.4M
Developing broad-spectrum therapeutics against C. difficile toxinsR01AI158503 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2021 to 2025
$3.9M
Structural basis for recognition of SV2 by type E botulinum neurotoxinR21AI163178 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2021 to 2022
$432k
NIAID NIH HHS R01 AI139087NIAID NIH HHS R01 AI158503NIAID NIH HHS R21 AI163178NIH HHS R01AI139087NIH HHS R01AI158503NIH HHS R21AI163178
6 · The paper itself

Abstract

As one of the most fatal substances, botulinum neurotoxins (BoNTs) have never acted solo to accomplish their formidable missions. Most notably, nontoxic nonhemagglutinin (NTNH), a protein co-secreted with BoNT by bacteria, plays critical roles to stabilize and protect BoNT by tightly associating with it to form the minimal progenitor toxin complex (M-PTC). A new cryo-EM structure of the M-PTC of a BoNT-like toxin from Weissella oryzae (BoNT/Wo) reveals similar assembly modes between M-PTC/Wo and that of other BoNTs, yet also reveals some unique structural features of NTNH/Wo. These findings shed new light on the potential versatile roles of NTNH during BoNT intoxication.

Indexed as

Botulinum ToxinsClostridium botulinumBiological TransportNeurotoxinsProteinsBotulinum ToxinsNeurotoxinsProteinsbotulinum neurotoxinbotulismnontoxic nonhemagglutininprogenitor toxin complex

Identifiers

PMID38009421
PMCPMC10922118
OpenAlexW4389038278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.