Evidence map›Paper›PMID 38009412›Full record

ArticleAging cell2023

SIRT2 transgenic over-expression does not impact lifespan in mice.

Lindsay E Wu, Corrine E Fiveash, Nicholas L Bentley, Myung-Jin Kang, Hemna Govindaraju, Jayne A Barbour, Brendan P Wilkins, Sarah E Hancock, Romanthi Madawala, Abhijit Das and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 2 countries.

Lindsay E WuSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.ORCID 0000-0002-1599-7574
Corrine E FiveashSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.
Nicholas L BentleySchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.
Myung-Jin KangSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.
Hemna GovindarajuSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.
Jayne A BarbourSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.ORCID 0000-0003-3587-7788
Brendan P WilkinsSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.
Sarah E HancockVictor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.ORCID 0000-0001-7541-8901
Romanthi MadawalaSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.
Abhijit DasSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.ORCID 0000-0003-3220-4975
Hassina MassudiSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.
Catherine LiSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.
Lynn-Jee KimSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.
Ashley S A WongSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.
Maria B MarinovaSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.
Ghazal SultaniSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.
Abhirup DasSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.
Neil A YoungsonSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.ORCID 0000-0003-0690-4580
David G Le CouteurANZAC Medical Research Institute, Concord, New South Wales, Australia.ORCID 0000-0002-4227-5817
David A SinclairDepartment of Genetics, Blavatnik Institute, Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School, Boston, Massachusetts, United States.ORCID 0000-0002-9936-436X
Nigel TurnerSchool of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia.ORCID 0000-0002-0119-9328
UNSW Sydney · AUVictor Chang Cardiac Research Institute · AUHarvard University · USThe University of Sydney · AU

Funding

American Federation for Aging Research AFAR/Hevolution New Investigator AwardNational Health and Medical Research Council APP1066172National Health and Medical Research Council APP1127821
6 · The paper itself

Abstract

The NAD

Indexed as

LongevitySirtuin 2AgingAnimalsAnimals, Genetically ModifiedBrainFemaleMaleMiceSirt2 protein, mouseSirtuin 2agingaging biologyhealthspanlifespanlongevitysirtuin 2 (SIRT2)sirtuins

Identifiers

PMID38009412
PMCPMC10726910
OpenAlexW4389038136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.