Evidence map›Paper›PMID 38009297›Full record

ArticleThe EMBO journal2023

GPNMB

Yan Meng, Qiudong Zhao, Yan Sang, Jianping Liao, Fei Ye, Shuping Qu, Pingping Nie, Liwei An, Weihong Zhang, Shi Jiao and 3 more

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Hypoxia-mediated mJournal of translational medicine · 2025
    Review
  3. From Bench to Bedside: Emerging Paradigms in CAR-T Cell Therapy for Solid Malignancies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. GPNMBThe EMBO journal · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Yan Meng *Tumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, Shanghai, China.ORCID 0009-0009-4240-3282
Qiudong Zhao *Tumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, Shanghai, China.ORCID 0000-0002-3884-2575
Yan Sang *Nursing Department, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.ORCID 0000-0003-0856-2318
Jianping Liao *The School of Basic Medical Sciences of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Fei YeTumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, Shanghai, China.
Shuping QuDepartment of Hepatic Surgery, the Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
Pingping NieDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai, China.
Liwei AnDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai, China.
Weihong ZhangDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai, China.ORCID 0000-0003-4099-4882
Shi JiaoState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, China.
Aimin HuangThe School of Basic Medical Sciences of Fujian Medical University, Fujian Medical University, Fuzhou, China.ORCID 0000-0002-3141-0315
Zhaocai ZhouDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai, China.ORCID 0000-0002-5441-3922
Lixin WeiTumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Second Military Medical University, Shanghai, China.ORCID 0000-0002-9526-5348
Tongji University · CNSecond Military Medical University · CNFujian Medical University · CNFudan University · CNNantong University · CN

Funding

National Key R&D Program of China 2020YFA0803200National Natural Science Foundation of China 31930026National Natural Science Foundation of China 32070710National Natural Science Foundation of China 81725014National Natural Science Foundation of China 81822035National Natural Science Foundation of China 81902806National Natural Science Foundation of China 81972599National Natural Science Foundation of China 81972876National Natural Science Foundation of China 82150112National Natural Science Foundation of China 82222052National Natural Science Foundation of China 82373251National Natural Science Foundation of China 92168116The Foundation of the Finance Department of Fujian Province of China 21SCZZX002
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) formation is a multi-step pathological process that involves evolution of a heterogeneous immunosuppressive tumor microenvironment. However, the specific cell populations involved and their origins and contribution to HCC development remain largely unknown. Here, comprehensive single-cell transcriptome sequencing was applied to profile rat models of toxin-induced liver tumorigenesis and HCC patients. Specifically, we identified three populations of hepatic parenchymal cells emerging during HCC progression, termed metabolic hepatocytes (HC

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAnimalsCarcinogenesisCell Transformation, NeoplasticHepatocytesHumansImmunosuppression TherapyMembrane GlycoproteinsRatsSOXF Transcription FactorsTumor MicroenvironmentGPNMB protein, humanMembrane GlycoproteinsSOX18 protein, humanSOXF Transcription Factorshepatocellular carcinomaimmunosuppressive microenvironmentmalignant transformation

Identifiers

PMID38009297
PMCPMC10711661
OpenAlexW4389038189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.