Evidence map›Paper›PMID 38008851›Full record

ReviewCurrent neurology and neuroscience reports2023

Vagus Nerve Stimulation in Ischemic Stroke.

Sasan Andalib, Afshin A Divani, Cenk Ayata, Sheharyar Baig, Ethem Murat Arsava, Mehmet Akif Topcuoglu, Eder Leonardo Cáceres, Vinay Parikh, Masoom J Desai, Arshad Majid and 2 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Effect of transcutaneous vagus nerve stimulation in hemodialysis patients: A randomized controlled trial.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
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  5. An integrated investigation of systemic and localized pathophysiological mechanisms of stroke and multimodal therapeutic strategies.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
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  7. [Research progress on the neuromodulation targets in stroke rehabilitation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 6 countries.

Sasan AndalibResearch Unit of Neurology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Afshin A DivaniDepartment of Neurology, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA. adivani@gmail.com.
Cenk AyataNeurovascular Research Unit, Department of Radiology and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Sheharyar BaigDepartment of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Ethem Murat ArsavaDepartment of Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Mehmet Akif TopcuogluDepartment of Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Eder Leonardo CáceresDepartment of Critical Care, Clínica de La Universidad de La Sabana, Chía, Colombia.
Vinay ParikhDepartment of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
Masoom J DesaiDepartment of Neurology, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA.
Arshad MajidDepartment of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Sara GirolamiNeurological Service, SS Annunziata Hospital, Sulmona, L'Aquila, Italy.
Mario Di NapoliNeurological Service, SS Annunziata Hospital, Sulmona, L'Aquila, Italy.
Hacettepe University · TROspedale SS. Annunziata · ITUniversity of New Mexico · USUniversity of Sheffield · GBMassachusetts General Hospital · USTemple University · USUniversidad de La Sabana · COUniversity of Southern Denmark · DK

Funding

Noninvasive Vagus Nerve Stimulation for Treatment of Brain Injury (nVNS-TBI) in RatsR21NS130423 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI DIVANI, AFSHIN ANDRE · 2022 to 2022
$419k
NINDS NIH HHS R21 NS130423
6 · The paper itself

Abstract

purpose of reviewVagus nerve stimulation (VNS) has emerged as a potential therapeutic approach for neurological and psychiatric disorders. In recent years, there has been increasing interest in VNS for treating ischemic stroke. This review discusses the evidence supporting VNS as a treatment option for ischemic stroke and elucidates its underlying mechanisms. RECENT

findingsPreclinical studies investigating VNS in stroke models have shown reduced infarct volumes and improved neurological deficits. Additionally, VNS has been found to reduce reperfusion injury. VNS may promote neuroprotection by reducing inflammation, enhancing cerebral blood flow, and modulating the release of neurotransmitters. Additionally, VNS may stimulate neuroplasticity, thereby facilitating post-stroke recovery. The Food and Drug Administration has approved invasive VNS (iVNS) combined with rehabilitation for ischemic stroke patients with moderate to severe upper limb deficits. However, iVNS is not feasible in acute stroke due to its time-sensitive nature. Non-invasive VNS (nVNS) may be an alternative approach for treating ischemic stroke. While the evidence from preclinical studies and clinical trials of nVNS is promising, the mechanisms through which VNS exerts its beneficial effects on ischemic stroke are still being elucidated. Therefore, further research is needed to better understand the efficacy and underlying mechanisms of nVNS in ischemic stroke. Moreover, large-scale randomized clinical trials are necessary to determine the optimal nVNS protocols, assess its long-term effects on stroke recovery and outcomes, and identify the potential benefits of combining nVNS with other rehabilitation strategies.

Indexed as

Brain IschemiaIschemic StrokeStrokeStroke RehabilitationVagus Nerve StimulationHumansUpper ExtremityAnti-inflammatoryBlood–brain barrierCortical spreading depolarizationIschemic strokeLocus coeruleusNeuroplasticityNon-invasive vagus nerve stimulationNucleus tractus solitariusStroke recoveryTraumatic brain injury

Identifiers

PMID38008851
PMCPMC10841711
OpenAlexW4389031786

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.