Evidence map›Paper›PMID 38008817›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2023

The lived experience of patients with breast cancer on adjuvant endocrine therapy: side effects and coping strategies during the first year of medication initiation.

Sameh Gomaa, AnaMaria Lopez, Rachel Slamon, Rita Smith, Emmanuel Lapitan, Ginah Nightingale, Suzanne M Miller, Kuang-Yi Wen

Abstract read
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Observational
  5. Beyond breast cancer: mapping unmet needs and advancing an evidence-based framework of survivorship care.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Return to work or leaving work? Differences of return to work between breast cancer patients and the general population and determinants of return to work.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Observational
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sameh GomaaDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
AnaMaria LopezDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
Rachel SlamonDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
Rita SmithDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
Emmanuel LapitanCancer Prevention and Control, Fox Chase Cancer Center/Temple University Health System, Philadelphia, PA, USA.
Ginah NightingaleDepartment of Pharmacy Practice, Thomas Jefferson University, Philadelphia, PA, USA.
Suzanne M MillerCancer Prevention and Control, Fox Chase Cancer Center/Temple University Health System, Philadelphia, PA, USA.
Kuang-Yi WenDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA. Kuang-Yi.Wen@jefferson.edu.

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI DANIEL P SILVER · 1995 to 2026
$94.8M
A Mobile TXT-based Intervention to Improve Adherence to Adjuvant Hormone Therapy and Symptom Management for BCa SurvivorsR01CA222246 · NCI · THOMAS JEFFERSON UNIVERSITY · PI WEN, KUANG-YI · 2019 to 2023
$2.8M
NCI NIH HHS 5R01CA222246-04NCI NIH HHS P30 CA056036NCI NIH HHS R01 CA222246
6 · The paper itself

Abstract

purposeAdjuvant endocrine therapy (AET) is pivotal for hormone receptor-positive breast cancer patients, significantly enhancing survival rates. Yet, adherence to AET remains challenging due to side effects. This study delves into the lived experience of breast cancer survivors concerning AET-induced side effects and examines differences in symptom profiles between Tamoxifen and aromatase inhibitors (AIs).

methodsWe interviewed 35 breast cancer survivors on AET, conducting qualitative iterative analysis using grounded theory. A codebook was developed to aid data coding and interpretation. NVIVO software facilitated comprehensive transcript analysis.

resultsSurvivors reported a spectrum of side effects like hot flashes, sexual issues, joint pain, stiffness, mood swings, and fertility concerns. Symptom profiles differed based on AET type. Tamoxifen users experienced more frequent sexual side effects and mood swings, while AIs were linked to joint pain, stiffness, and bone health worries. Those on AET for over 6 months expressed heightened concerns about side effects.

conclusionTailored patient education, aligned with AET type, empowers survivors to manage side effects using self-regulatory strategies. Acknowledging distinct symptom profiles enables informed decisions, improving adherence and quality of life. IMPLICATIONS: This study underscores tailored survivorship support, equipping patients with tools to manage side effects, enhancing adherence, and long-term outcomes. The findings inform the integration of comprehensive survivorship programs, emphasizing individualized strategies for managing side effects and promoting better adherence and improved quality of life.

Indexed as

Breast NeoplasmsAdaptation, PsychologicalAntineoplastic Agents, HormonalArthralgiaChemotherapy, AdjuvantFemaleHumansMedication AdherenceQuality of LifeTamoxifenAntineoplastic Agents, HormonalTamoxifenAdjuvant endocrine therapyMedication adherenceQuality of lifeSide effect management

Identifiers

PMID38008817
PMCPMC12576843

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.