ArticleNature communications2023
Modular interneuron circuits control motion sensitivity in the mouse retina.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Population-level geometric filtering generates motion-coherence selectivity in the retina.Science advances · 2026Article
- Distinct inhibitory connectivity motifs could trigger distinct forms of anticipation in the retinal network.Scientific reports · 2026Article
- The functional organization of retinal input to the mouse superior colliculus.bioRxiv : the preprint server for biology · 2026Article
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
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Authors and funding
7 authors.
Funding
Abstract
Neural computations arise from highly precise connections between specific types of neurons. Retinal ganglion cells (RGCs) with similar stratification patterns are positioned to receive similar inputs but often display different response properties. In this study, we used intersectional mouse genetics to achieve single-cell type labeling and identified an object motion sensitive (OMS) AC type, COMS-AC(counter-OMS AC). Optogenetic stimulation revealed that COMS-AC makes glycinergic synapses with the OMS-insensitive HD2p-RGC, while chemogenetic inactivation showed that COMS-AC provides inhibitory control to HD2p-RGC during local motion. This local inhibition, combined with the inhibitory drive from TH2-AC during global motion, explains the OMS-insensitive feature of HD2p-RGC. In contrast, COMS-AC fails to make synapses with W3(UHD)-RGC, allowing it to exhibit OMS under the control of VGlut3-AC and TH2-AC. These findings reveal modular interneuron circuits that endow structurally similar RGC types with different responses and present a mechanism for redundancy-reduction in the retina to expand coding capacity.
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Registered trials
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