Evidence map›Paper›PMID 38007518›Full record

ArticlePediatric research2024

Apolipoprotein-E4: risk of severe malaria and mortality and cognitive impairment in pediatric cerebral malaria.

Giselle Lima-Cooper, Benson J Ouma, Dibyadyuti Datta, Caitlin Bond, Alejandro A Soto, Andrea L Conroy, Gregory S Park, Paul Bangirana, Moses L Joloba, Robert O Opoka and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Giselle Lima-Cooper *Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Benson J Ouma *Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda.
Dibyadyuti DattaDepartment of Pediatrics, Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Caitlin BondDepartment of Pediatrics, Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Alejandro A SotoDepartment of Pediatrics, Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Andrea L ConroyDepartment of Pediatrics, Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Gregory S ParkOffice of the Vice President for Research, University of Minnesota, Minneapolis, MN, USA.
Paul BangiranaDepartment of Psychiatry, College of Health Sciences, Makerere University, Kampala, Uganda.
Moses L JolobaDepartment of Medical Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda.
Robert O OpokaDepartment of Pediatrics and Child Health, Makerere University, Kampala, Uganda.
Richard IdroDepartment of Pediatrics and Child Health, Makerere University, Kampala, Uganda.
Chandy C JohnDepartment of Pediatrics, Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA. chjohn@iu.edu.
Indiana University – Purdue University Indianapolis · USMakerere University · UGIndiana University School of MedicineUniversity of Minnesota · US

Funding

Severe Malaria And Risk to The Brain (SMART Brain)R01NS055349 · NINDS · UNIVERSITY OF MINNESOTA · PI Chandy C. John, Ruth Namazzi · 2008 to 2026
$11.2M
Research training in infection, nutrition and neurodevelopment in UgandaD43TW010928 · FIC · INDIANA UNIVERSITY INDIANAPOLIS · PI Chandy C. John · 2018 to 2026
$1.9M
Research Training in Infection and Neurodevelopment in UgandaD43NS078280 · NINDS · UNIVERSITY OF MINNESOTA · PI JOHN, CHANDY C. · 2011 to 2015
$1.1M
FIC NIH HHS D43 TW010928NINDS NIH HHS D43 NS078280NINDS NIH HHS R01 NS055349
6 · The paper itself

Abstract

backgroundThe relationship of apolipoprotein-E4 (APOE4) to mortality and cognition after severe malaria in children is unknown.

methodsAPOE genotyping was performed in children with cerebral malaria (CM, n = 261), severe malarial anemia (SMA, n = 224) and community children (CC, n = 213). Cognition was assessed over 2-year follow-up.

resultsA greater proportion of children with CM or SMA than CC had APOE4 (n = 162, 31.0%; n = 142, 31.7%; n = 103, 24.2%, respectively, p = 0.02), but no difference was seen in APOE3 (n = 310, 59.4%; n = 267, 59.6%; n = 282, 66.2%, respectively, p = 0.06), or APOE2 (n = 50, 9.6%; n = 39, 8.7%; and n = 41, 9.6%, respectively, p = 0.87). APOE4 was associated with increased mortality in CM (odds ratio, 2.28; 95% CI, 1.01, 5.11). However, APOE4 was associated with better long-term cognition (ß, 0.55; 95% CI, 0.04, 1.07, p = 0.04) and attention (ß 0.78; 95% CI, 0.26, 1.30, p = 0.004) in children with CM < 5 years old, but worse attention (ß, -0.90; 95% CI, -1.69, -0.10, p = 0.03) in children with CM ≥ 5 years old. Among children with CM, risk of post-discharge malaria was increased with APOE4 and decreased with APOE3.

conclusionsAPOE4 is associated with higher risk of CM or SMA and mortality in children with CM, but better long-term cognition in CM survivors <5 years of age.

Indexed as

Apolipoprotein E4Malaria, CerebralApolipoproteins EChildChild, PreschoolCognitionCognition DisordersFemaleGenotypeHumansInfantMaleRisk FactorsApoE protein, humanApolipoprotein E4Apolipoproteins E

Identifiers

PMID38007518
PMCPMC12009649
OpenAlexW4389002715

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.