Evidence map›Paper›PMID 38007405›Full record

ReviewCurrent microbiology2023

Antimicrobial Peptides Targeting Streptococcus mutans: Current Research on Design, Screening and Efficacy.

Xinxin Ying, Guanglu Xue, Pengxiang Sun, Ziling Gan, Ziqian Fan, Bo Liu, Yaoting Han, Jiaqian Yang, Jing Zhang, Aiping Lu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Combating Bacterial Infections with Vitamin D-Induced Antimicrobial Peptides.Advances in experimental medicine and biology · 2026
    Review
  3. Biofilm-targeted liposomal curcumin delivery system for anti-caries therapy.Frontiers in cellular and infection microbiology · 2026
    Article
  4. Article
  5. Review
  6. Dental plaque: Who is in the neighborhood and why it matters.Journal of the American Dental Association (1939) · 2025
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xinxin Ying *Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200010, China.
Guanglu Xue *Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200010, China.
Pengxiang Sun *Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200010, China.
Ziling Gan *Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200010, China.
Ziqian Fan *Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200010, China.
Bo Liu *Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200010, China.
Yaoting HanResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200010, China.
Jiaqian YangResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200010, China.
Jing ZhangResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200010, China. zhangjing@tongji.edu.cn.
Aiping LuResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200010, China. APLV@tongji.edu.cn.
Tongji University · CN

Funding

Shanghai Natural Science Foundation of China Grant 19ZR1461600
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are small-molecule peptides that play a vital role in the nonspecific immune defense system of organisms. They mainly kill microorganisms by physically destroying the cell membrane and causing the leakage of contents. AMPs have attracted much attention as potential alternatives to antibiotics due to their low susceptibility to resistance. Streptococcus mutans (S. mutans) is one of the main causative agents of human dental caries. The design, screening, and efficacy evaluation of AMPs targeting S. mutans offer new possibilities for the prevention and treatment of oral diseases, especially dental caries, in the future. This article reviews AMPs from different sources that have inhibitory effects on S. mutans, discusses the mechanism of action of AMPs against S. mutans biofilms, and focuses on the research progress of screening methods, design modification, and biological activity evaluation of AMPs. We hope to provide insights and reference value for the development of new biologics.

Indexed as

Dental CariesStreptococcus mutansAnti-Bacterial AgentsAntimicrobial PeptidesBiofilmsHumansAnti-Bacterial AgentsAntimicrobial Peptides

Identifiers

PMID38007405
OpenAlexW4388998239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.