Evidence map›Paper›PMID 38007183›Full record

Trial reportThe Journal of nutrition2024

The Collagen Synthesis Response to an Acute Bout of Resistance Exercise Is Greater when Ingesting 30 g Hydrolyzed Collagen Compared with 15 g and 0 g in Resistance-Trained Young Men.

Joonsung Lee, Jonathan C Y Tang, John Dutton, Rachel Dunn, William D Fraser, Kevin Enright, David R Clark, Claire E Stewart, Robert M Erskine

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  6. Review
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  13. Changes in Tendon Thickness After Chondrovita FITInternational journal of environmental research and public health · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Joonsung LeeSchool of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Jonathan C Y TangBioanalytical Facility, Norwich Medical School, University of East Anglia, Norwich, UK; Clinical Biochemistry, Departments of Laboratory Medicine, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK.
John DuttonBioanalytical Facility, Norwich Medical School, University of East Anglia, Norwich, UK.
Rachel DunnBioanalytical Facility, Norwich Medical School, University of East Anglia, Norwich, UK; Clinical Biochemistry, Departments of Laboratory Medicine, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK.
William D FraserBioanalytical Facility, Norwich Medical School, University of East Anglia, Norwich, UK; Clinical Biochemistry, Departments of Laboratory Medicine, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK; Departments of Diabetes and Endocrinology, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK.
Kevin EnrightSchool of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
David R ClarkSchool of Health Sciences, Robert Gordon University, Aberdeen, UK.
Claire E StewartSchool of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Robert M ErskineSchool of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK; Institute of Sport, Exercise and Health, University College London, London, UK. Electronic address: R.M.Erskine@ljmu.ac.uk.
University of East Anglia · GBLiverpool John Moores University · GBRobert Gordon University · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResistance exercise (RE) stimulates collagen synthesis in skeletal muscle and tendon but there is limited and equivocal evidence regarding an effect of collagen supplementation and exercise on collagen synthesis. Furthermore, it is not known if a dose-response exists regarding the effect of hydrolyzed collagen (HC) ingestion and RE on collagen synthesis.

objectiveTo determine the HC dose-response effect on collagen synthesis after high-intensity RE in resistance-trained young men.

methodsUsing a double-blind, randomized crossover design, 10 resistance-trained males (age: 26 ± 3 y; height: 1.77 ± 0.04 m; mass: 79.7 ± 7.0 kg) ingested 0 g, 15 g, or 30 g HC with 50 mg vitamin C 1 h before performing 4 sets' barbell back squat RE at 10-repetition maximum load, after which they rested for 6 h. Blood samples were collected throughout each of the 3 interventions to analyze procollagen type Ⅰ N-terminal propeptide (PINP) and β-isomerized C-terminal telopeptide of type I collagen (β-CTX) concentration, and the concentration of 18 collagen amino acids.

resultsThe serum PINP concentration × time area under the curve (AUC) was greater for 30 g (267 ± 79 μg·L

conclusionsIngesting 30 g HC before high-intensity RE augments whole-body collagen synthesis more than 15 g and 0 g HC in resistance-trained young males.

Indexed as

CollagenCross-Over StudiesResistance TrainingAdultCollagen Type IDietary SupplementsDose-Response Relationship, DrugDouble-Blind MethodExerciseHumansMaleMuscle, SkeletalPeptide FragmentsProcollagenYoung AdultCollagenCollagen Type IPeptide FragmentsProcollagenconnective tissueglycinehydroxyprolineprolinestrength trainingvitamin C

Identifiers

PMID38007183
PMCPMC11282471
OpenAlexW4388974376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.