Evidence map›Paper›PMID 38006669›Full record

ArticleDrug and alcohol dependence2023

Mindfulness and clinical correlates in methamphetamine use disorder.

Olivia Jarrett, Edythe D London, Tarannom Mahmoudie, Jaymee Suh, Dara Ghahremani, Andy C Dean

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olivia JarrettDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and human Behavior, David Geffen School of Medicine, USA.
Edythe D LondonDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and human Behavior, David Geffen School of Medicine, USA; Department of Molecular and Medical Pharmacology, USA; Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA.
Tarannom MahmoudieDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and human Behavior, David Geffen School of Medicine, USA.
Jaymee SuhDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and human Behavior, David Geffen School of Medicine, USA.
Dara GhahremaniDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and human Behavior, David Geffen School of Medicine, USA; Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA.
Andy C DeanDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and human Behavior, David Geffen School of Medicine, USA; Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA. Electronic address: acdean@mednet.ucla.edu.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
Exercise in Methamphetamine Use Disorder: Dopamine Receptor Upregulation and Neural FunctionR01DA045162 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK, MOONEY, LARISSA JEANETTE · 2018 to 2022
$3.3M
Neurobehavioral Predictors of Cognitive Decline in Methamphetamine DependenceK23DA027734 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEAN, ANDREW CLARK · 2010 to 2014
$842k
CYP2D6, brain structure, and cognitive function in methamphetamine dependenceR21DA034928 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEAN, ANDREW CLARK · 2013 to 2014
$424k
NCATS NIH HHS UL1 TR000124NCRR NIH HHS M01 RR000865NIDA NIH HHS K23 DA027734NIDA NIH HHS R01 DA045162NIDA NIH HHS R21 DA034928
6 · The paper itself

Abstract

backgroundMindfulness-based interventions are increasingly used for the treatment of substance use disorders, including methamphetamine use disorder (MUD). Literature indicates that trait mindfulness may play a key role in the effectiveness of these treatments on therapeutic outcome, yet no prior studies have tested for differences in trait mindfulness between individuals with MUD and healthy control participants. Such differences are important for treatment implementation.

objectivesThe goals of this study were to evaluate trait mindfulness and to determine its clinical correlates in individuals with MUD.

methodsA group of participants with MUD at varying lengths of abstinence from methamphetamine (< 1h to 90 days; mean 5.4 ± 12.5 days; N=95, 53 female, 42 male) and a healthy control group (N=65, 30 female, 35 male) completed the Mindfulness Attention Awareness Scale (MAAS). Group differences and relationships between trait mindfulness and several measures of drug use and psychiatric symptoms were evaluated.

resultsIn participants with MUD, trait mindfulness was 10% lower than in healthy controls (p < 0.001), but it was not significantly correlated with measures of drug use or craving. Across both groups, trait mindfulness was negatively correlated with state anxiety, depression, emotional dysregulation, impulsivity, and a history of childhood trauma, while it was positively correlated with self-compassion (ps < 0.001).

conclusionThe deficit in trait mindfulness in MUD presents a capacity that can be targeted for improved treatment outcome with mindfulness-based therapies. Trait mindfulness is inversely related to mood dysregulation.

Indexed as

MethamphetamineMindfulnessSubstance-Related DisordersAffectFemaleHumansMaleTreatment OutcomeMethamphetamineImpulsivityMethamphetamine Use Disorder (MUD)Negative AffectTrait Mindfulness

Identifiers

PMID38006669
PMCPMC13353770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.