Evidence map›Paper›PMID 38006624›Full record

ArticleJournal of molecular graphics & modelling2024

GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism.

Stefano Costanzi, Lea G Stahr, Giampaolo Trivellin, Constantine A Stratakis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular graphics & modelling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Stefano CostanziAmerican University, Department of Chemistry, Washington, DC, USA. Electronic address: costanzi@american.edu.
Lea G StahrAmerican University, Department of Chemistry, Washington, DC, USA.
Giampaolo TrivellinDepartment of Biomedical Sciences, Humanitas University, Milan, Italy; IRCCS Humanitas Research Hospital, Milan, Italy.
Constantine A StratakisFORTH, Heraklion, Greece; ELPEN Research Institute, Athens, Greece.
American University · USElpen Pharmaceutical (Greece) · GRHumanitas University · IT

Funding

Virtual screening for the identification of ligands of GPR101, an orphan GPCR involved in X-linked acrogigantism (X-LAG)R15GM141731 · NIGMS · AMERICAN UNIVERSITY · PI COSTANZI, STEFANO · 2021 to 2021
$429k
NIGMS NIH HHS R15 GM141731
6 · The paper itself

Abstract

GPR101 is a G protein-coupled receptor (GPCR) implicated in a rare form of genetic gigantism known as X-linked acrogigantism, or X-LAG. In particular, X-LAG patients harbor microduplications in the long arm of the X-chromosome that invariably include the GPR101 gene. Duplications of the GPR101 gene lead to the formation of a new chromatin domain that causes over-expression of the receptor in the pituitary tumors of the patients. Notably, GPR101 is a constitutively active receptor, which stimulates cells to produce the second messenger cyclic AMP (cAMP) in the absence of ligands. Moreover, GPR101 was recently reported to constitutively activate not only the cAMP pathway via G

Indexed as

AcromegalyGigantismCryoelectron MicroscopyDrug Inverse AgonismHumansReceptors, G-Protein-CoupledGPR101 protein, humanReceptors, G-Protein-CoupledAlphaFoldAlphaFold-multistateGPR101G protein-coupled receptors (GPCRs)Homology modelingMolecular dynamics

Identifiers

PMID38006624
PMCPMC10843723
OpenAlexW4388872030

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.