Evidence map›Paper›PMID 38006008›Full record

ArticleVaccines2023

Age and Comorbidities as Risk Factors for Severe COVID-19 in Mexico, before, during and after Massive Vaccination.

Lenin Domínguez-Ramírez, Francisca Sosa-Jurado, Guadalupe Díaz-Sampayo, Itzel Solis-Tejeda, Francisco Rodríguez-Pérez, Rosana Pelayo, Gerardo Santos-López, Paulina Cortes-Hernandez

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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  3. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lenin Domínguez-RamírezPopulation Health and Metadynamics Lab, Centro de Investigacion Biomedica de Oriente, Instituto Mexicano del Seguro Social Atlixco, Atlixco 74360, Puebla, Mexico.
Francisca Sosa-JuradoVirology Lab, Centro de Investigacion Biomedica de Oriente, Instituto Mexicano del Seguro Social, Atlixco 74360, Puebla, Mexico.ORCID 0000-0001-9959-2162
Guadalupe Díaz-SampayoPopulation Health and Metadynamics Lab, Centro de Investigacion Biomedica de Oriente, Instituto Mexicano del Seguro Social Atlixco, Atlixco 74360, Puebla, Mexico.
Itzel Solis-TejedaPopulation Health and Metadynamics Lab, Centro de Investigacion Biomedica de Oriente, Instituto Mexicano del Seguro Social Atlixco, Atlixco 74360, Puebla, Mexico.
Francisco Rodríguez-PérezPopulation Health and Metadynamics Lab, Centro de Investigacion Biomedica de Oriente, Instituto Mexicano del Seguro Social Atlixco, Atlixco 74360, Puebla, Mexico.
Rosana PelayoOncoimmunology and Cytomics Lab, Centro de Investigacion Biomedica de Oriente, Instituto Mexicano del Seguro Social, Atlixco 74360, Puebla, Mexico.
Gerardo Santos-LópezVirology Lab, Centro de Investigacion Biomedica de Oriente, Instituto Mexicano del Seguro Social, Atlixco 74360, Puebla, Mexico.ORCID 0000-0002-3793-3117
Paulina Cortes-HernandezPopulation Health and Metadynamics Lab, Centro de Investigacion Biomedica de Oriente, Instituto Mexicano del Seguro Social Atlixco, Atlixco 74360, Puebla, Mexico.ORCID 0000-0001-8226-1703
Mexican Social Security Institute · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During 2020-2023, Mexico had a large COVID-19 emergency with >331,000 adult deaths and one of the highest excess mortalities worldwide. Age at COVID-19 death has been lower in Mexico than in high-income countries, presumably because of the young demographics and high prevalence of chronic metabolic diseases in young and middle-aged adults. SARS-CoV-2 vaccination covered 85% of adults with at least one dose and 50% with booster(s) up to April 2022. No new vaccination efforts or updated boosters were introduced until October 2023; thus, we explored the public health impact of massive SARS-CoV-2 vaccination against ancestral strains and asked whether their real-world protection has persisted through time. We compared three periods with respect to vaccine roll-outs: before, during and after vaccine introduction in a national retrospective cohort of >7.5 million COVID-19 cases. The main findings were that after vaccination, COVID-19 mortality decreased, age at COVID-19 death increased by 5-10 years, both in populations with and without comorbidities; obesity stopped being a significant risk factor for COVID-19 death and protection against severe disease persisted for a year after boosters, including at ages 60-79 and 80+. Middle-aged adults had the highest protection from vaccines/hybrid immunity and they more than halved their proportions in COVID-19 deaths.

Indexed as

chronic kidney diseaseCOVID-19diabetesmassive vaccination in Mexicomiddle-age adultsobesitySARS-CoV-2 vaccines

Identifiers

PMID38006008
PMCPMC10674414
OpenAlexW4388233606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.