Evidence map›Paper›PMID 38006002›Full record

ArticleVaccines2023

Humoral and Cellular Immunity Are Significantly Affected in Renal Transplant Recipients, following Vaccination with BNT162b2.

Asimina Fylaktou, Stamatia Stai, Efstratios Kasimatis, Aliki Xochelli, Vasiliki Nikolaidou, Anastasia Papadopoulou, Grigorios Myserlis, Georgios Lioulios, Despoina Asouchidou, Maria Giannaki and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Asimina FylaktouDepartment of Immunology, National Histocompatibility Center, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Stamatia StaiDepartment of Nephrology, Hippokration Hospital, 54642 Thessaloniki, Greece.
Efstratios KasimatisDepartment of Nephrology, Hippokration Hospital, 54642 Thessaloniki, Greece.ORCID 0000-0001-7027-1402
Aliki XochelliDepartment of Immunology, National Histocompatibility Center, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Vasiliki NikolaidouDepartment of Immunology, National Histocompatibility Center, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Anastasia PapadopoulouHematology Department-Hematopoietic Cell Transplantation Unit, Gene and Cell Therapy Center, "George Papanikolaou" Hospital, 57010 Thessaloniki, Greece.
Grigorios MyserlisDepartment of Transplant Surgery, Hippokration Hospital, 54642 Thessaloniki, Greece.
Georgios LiouliosDepartment of Nephrology, Hippokration Hospital, 54642 Thessaloniki, Greece.
Despoina AsouchidouDepartment of Immunology, National Histocompatibility Center, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Maria GiannakiHematology Department-Hematopoietic Cell Transplantation Unit, Gene and Cell Therapy Center, "George Papanikolaou" Hospital, 57010 Thessaloniki, Greece.
Evangelia YannakiHematology Department-Hematopoietic Cell Transplantation Unit, Gene and Cell Therapy Center, "George Papanikolaou" Hospital, 57010 Thessaloniki, Greece.
Georgios TsoulfasSchool of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-5043-7962
Aikaterini PapagianniDepartment of Nephrology, Hippokration Hospital, 54642 Thessaloniki, Greece.
Maria StangouDepartment of Nephrology, Hippokration Hospital, 54642 Thessaloniki, Greece.ORCID 0000-0003-2496-9863
Hippocration General Hospital · GRAristotle University of Thessaloniki · GRG. Papanikolaou General Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRenal transplant recipients (RTRs) tend to mount weaker immune responses to vaccinations, including vaccines against the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

methodsHumoral immunity was assessed using anti-receptor binding domain (RBD) and neutralizing antibodies (NAb) serum levels measured by ELISA, and cellular immunity was assessed using T-, B-, NK, natural killer-like T (NKT)-cell subpopulations, and monocytes measured by flow cytometry, and also specific T-cell immunity, at predefined time points after BNT162b2 vaccination, in 57 adult RTRs.

resultsAdministration of three booster doses was necessary to achieve anti-RBD and NAb protective levels in almost all patients (92.98%). Ab production, at several time points, was positively correlated with the corresponding renal function and inversely correlated with hemodialysis vintage (HDV) and treatment with mycophenolic acid (MPA). A gradual rise in several cell subpopulations, including total lymphocytes (

conclusionsSARS-CoV-2-specific T-cell responses preceded the humoral ones, while two booster doses were needed for this group of immunocompromised patients to mount a protective immune response.

Indexed as

cellular responseELISpothumoral responserenal transplantationSARS-CoV-2vaccination

Identifiers

PMID38006002
PMCPMC10674678
OpenAlexW4388041373

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.