Evidence map›Paper›PMID 38005960›Full record

ReviewVaccines2023

Vaccination and Antiviral Treatment against Avian Influenza H5Nx Viruses: A Harbinger of Virus Control or Evolution.

Ahlam Alasiri, Raya Soltane, Akram Hegazy, Ahmed Magdy Khalil, Sara H Mahmoud, Ahmed A Khalil, Luis Martinez-Sobrido, Ahmed Mostafa

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Ahlam AlasiriDepartment of Basic Sciences, Adham University College, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0002-0095-4563
Raya SoltaneDepartment of Basic Sciences, Adham University College, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0002-3211-4630
Akram HegazyDepartment of Agricultural Microbiology, Faculty of Agriculture, Cairo University, Giza District, Giza 12613, Egypt.ORCID 0000-0002-2489-9036
Ahmed Magdy KhalilTexas Biomedical Research Institute, San Antonio, TX 78227, USA.
Sara H MahmoudCenter of Scientific Excellence for Influenza Viruses, National Research Center, Giza 12622, Egypt.
Ahmed A KhalilVeterinary Sera and Vaccines Research Institute (VSVRI), Agriculture Research Center (ARC), Cairo 11435, Egypt.ORCID 0000-0002-2920-1178
Luis Martinez-SobridoTexas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0001-7084-0804
Ahmed MostafaTexas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0002-2878-5714
Texas Biomedical Research Institute · USUmm al-Qura University · SACairo University · EGNational Water Research Center · EG

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
Development of a High-Throughput Microfluidics-Enabled Functional Assay for Rapidly Identifying Neutralizing AntibodiesR01AI141607 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI DE FIGUEIREDO, PAUL, HAN, ARUM · 2019 to 2023
$3.4M
Dynamics of the protective vaccine-induced human influenza neuraminidase B cell responseR01AI145332 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KOBIE, JAMES J, MARTINEZ-SOBRIDO, LUIS · 2019 to 2022
$3.0M
NIAID NIH HHS 75N93021C00014NIAID NIH HHS R01 AI141607NIAID NIH HHS R01 AI145332
6 · The paper itself

Abstract

Despite the panzootic nature of emergent highly pathogenic avian influenza H5Nx viruses in wild migratory birds and domestic poultry, only a limited number of human infections with H5Nx viruses have been identified since its emergence in 1996. Few countries with endemic avian influenza viruses (AIVs) have implemented vaccination as a control strategy, while most of the countries have adopted a culling strategy for the infected flocks. To date, China and Egypt are the two major sites where vaccination has been adopted to control avian influenza H5Nx infections, especially with the widespread circulation of clade 2.3.4.4b H5N1 viruses. This virus is currently circulating among birds and poultry, with occasional spillovers to mammals, including humans. Herein, we will discuss the history of AIVs in Egypt as one of the hotspots for infections and the improper implementation of prophylactic and therapeutic control strategies, leading to continuous flock outbreaks with remarkable virus evolution scenarios. Along with current pre-pandemic preparedness efforts, comprehensive surveillance of H5Nx viruses in wild birds, domestic poultry, and mammals, including humans, in endemic areas is critical to explore the public health risk of the newly emerging immune-evasive or drug-resistant H5Nx variants.

Indexed as

antiviral treatmentavian influenza virusesH5Nxvaccinationvirus evolution

Identifiers

PMID38005960
PMCPMC10675773
OpenAlexW4387904209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.