Evidence map›Paper›PMID 38005942›Full record

ArticleViruses2023

Presence and Persistence of Andes Virus RNA in Human Semen.

Roland Züst, Rahel Ackermann-Gäumann, Nicole Liechti, Denise Siegrist, Sarah Ryter, Jasmine Portmann, Nicole Lenz, Christian Beuret, Roger Koller, Cornelia Staehelin and 4 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Andes Virus: From Transmission Dynamics to Pandemic Potential.European journal of clinical investigation · 2026
    Review
  3. Andes hantavirus - A primer.Npj viruses · 2026
    Article
  4. Why Andes hantavirus is not the next SARS-CoV-2: contrasting viral shedding, transmissibility and genomic patterns.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Roland ZüstSpiez Laboratory, Swiss Federal Office for Civil Protection, 3700 Spiez, Switzerland.
Rahel Ackermann-GäumannADMED Microbiology, 2300 La Chaux-de-Fonds, Switzerland.ORCID 0000-0002-9761-8071
Nicole LiechtiSpiez Laboratory, Swiss Federal Office for Civil Protection, 3700 Spiez, Switzerland.ORCID 0000-0003-4354-2419
Denise SiegristSpiez Laboratory, Swiss Federal Office for Civil Protection, 3700 Spiez, Switzerland.
Sarah RyterSpiez Laboratory, Swiss Federal Office for Civil Protection, 3700 Spiez, Switzerland.
Jasmine PortmannSpiez Laboratory, Swiss Federal Office for Civil Protection, 3700 Spiez, Switzerland.
Nicole LenzFood Microbial Systems, Risk Assessment and Mitigation Group, Agroscope, 3097 Bern, Switzerland.
Christian BeuretSpiez Laboratory, Swiss Federal Office for Civil Protection, 3700 Spiez, Switzerland.
Roger KollerInstitute for Infectious Diseases, University of Bern, 3001 Bern, Switzerland.ORCID 0000-0002-8502-9704
Cornelia StaehelinDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0002-1733-7051
Andrea B KuenzliDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Jonas MarschallDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Sylvia RothenbergerSpiez Laboratory, Swiss Federal Office for Civil Protection, 3700 Spiez, Switzerland.ORCID 0000-0001-8633-2994
Olivier EnglerSpiez Laboratory, Swiss Federal Office for Civil Protection, 3700 Spiez, Switzerland.ORCID 0000-0002-8404-1496
Spiez Laboratory · CHUniversity of Bern · CHADMED (Switzerland) · CHAgroscope · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When infecting humans, Andes orthohantavirus (ANDV) may cause a severe disease called hantavirus cardiopulmonary syndrome (HCPS). Following non-specific symptoms, the infection may progress to a syndrome of hemorrhagic fever combined with hyper-acute cardiopulmonary failure. The case fatality rate ranges between 25-40%, depending on the outbreak. In this study, we present the follow-up of a male patient who recovered from HCPS six years ago. We demonstrate that the ANDV genome persists within the reproductive tract for at least 71 months. Genome sequence analysis early and late after infection reveals a low number of mutations (two single nucleotide variants and one deletion), suggesting limited replication activity. We can exclude the integration of the viral genome into the host genome, since the treatment of the specimen with RNAse led to a loss of signal. We demonstrate a long-lasting, strong neutralizing antibody response using pseudovirions expressing the ANDV glycoprotein. Taken together, our results show that ANDV has the potential for sexual transmission.

Indexed as

Hantavirus InfectionsOrthohantavirusAntibodies, NeutralizingHumansMaleRNA, ViralSemenAntibodies, NeutralizingRNA, ViralAndes virusneutralizing antibodiespersistencesemen

Identifiers

PMID38005942
PMCPMC10675069
OpenAlexW4388772860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.