Evidence map›Paper›PMID 38005889›Full record

ArticleViruses2023

Features of Tat Protein in HIV-1 Sub-Subtype A6 Variants Circulating in the Moscow Region, Russia.

Anna Kuznetsova, Kristina Kim, Alexander Tumanov, Iana Munchak, Anastasiia Antonova, Aleksey Lebedev, Ekaterina Ozhmegova, Elena Orlova-Morozova, Elena Drobyshevskaya, Alexander Pronin and 2 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Anna KuznetsovaGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.ORCID 0000-0001-5299-3081
Kristina KimGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.
Alexander TumanovGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.
Iana MunchakGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.
Anastasiia AntonovaGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.ORCID 0000-0002-9180-9846
Aleksey LebedevGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.ORCID 0000-0001-6787-9345
Ekaterina OzhmegovaGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.ORCID 0000-0002-3110-0843
Elena Orlova-MorozovaMoscow Regional Center for the Prevention and Control of AIDS and Infectious Diseases, 129110 Moscow, Russia.
Elena DrobyshevskayaMoscow Regional Center for the Prevention and Control of AIDS and Infectious Diseases, 129110 Moscow, Russia.ORCID 0000-0002-0654-8646
Alexander ProninMoscow Regional Center for the Prevention and Control of AIDS and Infectious Diseases, 129110 Moscow, Russia.
Aleksey PrilipovGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.
Elena KazennovaGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.
Gamalei Institute of Epidemiology and Microbiology · RURegional Center for Prevention and Control of AIDS and Infectious Diseases · RU

Funding

the Russian Science Foundation 23-15-00027
6 · The paper itself

Abstract

Tat, the trans-activator of transcription, is a multifunctional HIV-1 protein that can induce chronic inflammation and the development of somatic diseases in HIV-infected patients. Natural polymorphisms in Tat can impact the propagation of the inflammatory signal. Currently, Tat is considered an object for creating new therapeutic agents. Therefore, the identification of Tat protein features in various HIV-1 variants is a relevant task. The purpose of the study was to characterize the genetic variations of Tat-A6 in virus variants circulating in the Moscow Region. The authors analyzed 252 clinical samples from people living with HIV (PLWH) with different stages of HIV infection. Nested PCR for two fragments (

Indexed as

HIV-1HIV InfectionsGene Products, tatHumansMoscowRussiatat Gene Products, Human Immunodeficiency VirusGene Products, tattat Gene Products, Human Immunodeficiency VirusHIV-1Moscow RegionRussiasub-subtype A6Tat

Identifiers

PMID38005889
PMCPMC10675479
OpenAlexW4388334185

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.