Evidence map›Paper›PMID 38005888›Full record

ArticleViruses2023

Human Complement Inhibits Myophages against

Julia E Egido, Simon O Dekker, Catherine Toner-Bartelds, Cédric Lood, Suzan H M Rooijakkers, Bart W Bardoel, Pieter-Jan Haas

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Immune Responses to Phage Therapy in Humans: A Review.The Journal of infectious diseases · 2026
    Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Julia E EgidoDepartment of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0000-0001-6590-2054
Simon O DekkerDepartment of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Catherine Toner-BarteldsDepartment of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Cédric LoodLaboratory of Gene Technology, Department of Biosystems, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.ORCID 0000-0001-7826-3378
Suzan H M RooijakkersDepartment of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0000-0003-4102-0377
Bart W BardoelDepartment of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0000-0001-6450-277X
Pieter-Jan HaasDepartment of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0000-0002-1127-095X
University Medical Center Utrecht · NLKU Leuven · BE

Funding

NCOH no numberResearch Foundation - Flanders 12D8623N
6 · The paper itself

Abstract

Therapeutic bacteriophages (phages) are primarily chosen based on their in vitro bacteriolytic activity. Although anti-phage antibodies are known to inhibit phage infection, the influence of other immune system components is less well known. An important anti-bacterial and anti-viral innate immune system that may interact with phages is the complement system, a cascade of proteases that recognizes and targets invading microorganisms. In this research, we aimed to study the effects of serum components such as complement on the infectivity of different phages targeting

Indexed as

BacteriophagesPseudomonas InfectionsPseudomonas PhagesBacteriolysisHumansPseudomonas aeruginosacomplement systemphage therapyPseudomonas aeruginosa

Identifiers

PMID38005888
PMCPMC10674969
OpenAlexW4388334179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.