Evidence map›Paper›PMID 38005530›Full record

ArticleSensors (Basel, Switzerland)2023

Quantitative Colorimetric Sensing of Carbidopa in Anti-Parkinson Drugs Based on Selective Reaction with Indole-3-Carbaldehyde.

Pasquale Palladino, Alberto Rainetti, Mariagrazia Lettieri, Giuseppe Pieraccini, Simona Scarano, Maria Minunni

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Pasquale PalladinoDepartment of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-3869-5085
Alberto RainettiDepartment of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy.
Mariagrazia LettieriDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy.ORCID 0000-0001-6945-7576
Giuseppe PieracciniCISM Mass Spectrometry Centre, University of Florence, Viale Gaetano Pieraccini 6, 50139 Florence, Italy.ORCID 0000-0003-3103-3924
Simona ScaranoDepartment of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-8050-1715
Maria MinunniDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126 Pisa, Italy.
University of Florence · ITUniversity of Pisa · ITUniversity of Siena · IT

Funding

Ministry of University and Reseach (MUR), Italy Dipartimenti di Eccellenza 2023-2027 (DICUS 2.0)University of Florence RICATEN 2022
6 · The paper itself

Abstract

The quality of life of patients affected by Parkinson's disease is improved by medications containing levodopa and carbidopa, restoring the dopamine concentration in the brain. Accordingly, the affordable quality control of such pharmaceuticals is very important. Here is reported the simple and inexpensive colorimetric quantification of carbidopa in anti-Parkinson drugs by the selective condensation reaction between the hydrazine group from carbidopa and the formyl functional group of selected aldehydes in acidified hydroalcoholic solution. An optical assay was developed by using indole-3-carbaldehyde (I3A) giving a yellow aldazine in EtOH:H

Indexed as

CarbidopaQuality of LifeAntiparkinson AgentsColorimetryHumansIndolesLevodopaReproducibility of ResultsAntiparkinson AgentsCarbidopaindole-3-carbaldehydeIndolesLevodopaaldazineanti-Parkinson drugscarbidopacolorimetryindole-3-carbaldehydelevodopa

Identifiers

PMID38005530
PMCPMC10674578
OpenAlexW4388630240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.