Evidence map›Paper›PMID 38005381›Full record

ReviewMolecules (Basel, Switzerland)2023

Strategies for the Preparation of Chitosan Derivatives for Antimicrobial, Drug Delivery, and Agricultural Applications: A Review.

Rajeev Shrestha, Anusree Thenissery, Rahul Khupse, Gireesh Rajashekara

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rajeev ShresthaCenter for Food Animal Health, Department of Animal Sciences, The Ohio State University, Wooster, OH 44691, USA.
Anusree ThenisseryCenter for Food Animal Health, Department of Animal Sciences, The Ohio State University, Wooster, OH 44691, USA.ORCID 0000-0002-4219-075X
Rahul KhupseCollege of Pharmacy, University of Findlay, Findlay, OH 45840, USA.
Gireesh RajashekaraCenter for Food Animal Health, Department of Animal Sciences, The Ohio State University, Wooster, OH 44691, USA.ORCID 0000-0003-2443-6733

Funding

U.S. Department of Agriculture (USDA), National Institute for Food and Agriculture (NIFA), United States Department of Agriculture Specialty Crops Research Initiative project awards 2015-68004-23131, 2020-6701-31401, 2019-51181-30010, and 2022-51181-38242
6 · The paper itself

Abstract

Chitosan has received much attention for its role in designing and developing novel derivatives as well as its applications across a broad spectrum of biological and physiological activities, owing to its desirable characteristics such as being biodegradable, being a biopolymer, and its overall eco-friendliness. The main objective of this review is to explore the recent chemical modifications of chitosan that have been achieved through various synthetic methods. These chitosan derivatives are categorized based on their synthetic pathways or the presence of common functional groups, which include alkylated, acylated, Schiff base, quaternary ammonia, guanidine, and heterocyclic rings. We have also described the recent applications of chitosan and its derivatives, along with nanomaterials, their mechanisms, and prospective challenges, especially in areas such as antimicrobial activities, targeted drug delivery for various diseases, and plant agricultural domains. The accumulation of these recent findings has the potential to offer insight not only into innovative approaches for the preparation of chitosan derivatives but also into their diverse applications. These insights may spark novel ideas for drug development or drug carriers, particularly in the antimicrobial, medicinal, and plant agricultural fields.

Indexed as

Anti-Infective AgentsChitosanDrug CarriersDrug Delivery SystemsProspective StudiesAnti-Infective AgentsChitosanDrug Carriersantimicrobial activitychitosan (CS) derivativesdrug deliveryinfectious diseasesplant agriculture

Identifiers

PMID38005381
PMCPMC10674490

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.