ReviewMaterials (Basel, Switzerland)2023
The Effectiveness of Autologous Platelet Concentrates in the Clinical and Radiographic Healing after Endodontic Surgery: A Systematic Review.
Review in Materials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Effectiveness of concentrated growth factors with or without grafting materials in maxillary sinus augmentation: a systematic review.BMC oral health · 2024Pooled it
- Indications for endodontic surgery in private practice and temporal trends before and after adoption of laser-activated irrigation: a retrospective practice-based study.Clinical oral investigations · 2026Article
- Advances in Regenerative Dentistry: From Biological Mechanisms to Clinical Translation.Life (Basel, Switzerland) · 2026Review
- Clinical Outcomes of Platelet-Rich Fibrin in Endodontic Microsurgery: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Influence of kinematic motion and instrumentation strategy on apical debris extrusion during root canal preparation: AnJournal of conservative dentistry and endodontics · 2026Article
- Two-dimensional and three-dimensional evaluation of bone regeneration using platelet-rich fibrin versus bone putty in large periapical lesions after endodontic surgery: A randomized clinical trial.Journal of conservative dentistry and endodontics · 2026Article
- Cytotoxicity of Root Canal Sealers and Potential Clinical Implications: A Comprehensive Systematic Review of In Vitro Studies.Journal of clinical medicine · 2026Review
- Long-term outcomes of platelet-rich fibrin and blood clot scaffolds in regenerative endodontic treatment of traumatized immature maxillary incisors: An 80-month case report.Frontiers in dental medicine · 2026Article
- Effect of guided tissue regeneration on the outcome of surgical endodontic treatment: An umbrella review.Journal of conservative dentistry and endodontics · 2025Review
- Micro- and Nanoplastics and the Oral Cavity: Implications for Oral and Systemic Health, Dental Practice, and the Environment-A Narrative Review.Journal of functional biomaterials · 2025Review
- Dynamic Navigation in Endodontic Surgery: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Platelet-Rich Plasma and Platelet-Rich Fibrin in Endodontics: A Scoping Review.International journal of molecular sciences · 2025Article
- PRF and PRP in Dentistry: An Umbrella Review.Journal of clinical medicine · 2025Review
- Use of a Resorbable Magnesium Membrane for Bone Regeneration After Large Radicular Cyst Removal: A Clinical Case Report.Healthcare (Basel, Switzerland) · 2025Article
- The tooth transformer® revolution: autologous dentin biomaterials and platelet concentrates in oral regeneration. A parallel narrative systematic review.Frontiers in dental medicine · 2025Review
- The Role of Autologous Platelet Concentrates as a Local Antibiotic Delivery System: A Systematic Scoping Review.Antibiotics (Basel, Switzerland) · 2024Article
- Effectiveness of Injectable Platelet-Rich Fibrin Therapy in Alopecia and Facial Rejuvenation: A Systematic Review.Cureus · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regenerative techniques are increasingly applied in endodontic surgery, but different materials may have varying impacts on soft and hard tissue healing. This systematic review aims to evaluate the effectiveness of autologous platelet concentrates (APCs) in clinical and radiographic healing after endodontic surgery. The data for this systematic review were processed following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for improving the reporting of systematic reviews and meta-analyses. A literature search was conducted until October 2023 on PubMed, Scopus, and Cochrane Databases. Randomized controlled trials and controlled clinical trials addressing the use of APCs in patients who presented persistent periapical lesions and needed periapical surgery were included. Dual publications, narrative reviews, systematic reviews, case series, questionnaires, animal studies, case reports, letters to the editor, in vitro studies, and abstracts were excluded. In total, the search resulted in 14 papers. Clinical and radiographical findings were reported, showing that when APCs were used, patients exhibited less pain and swelling and a greater reduction of apical radiolucency after 12 months follow-up on average. However, the moderate/high risk of bias of included studies and their high heterogeneity, do not allow one to draw definitive conclusions on the effectiveness of APC after endodontic surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.