Evidence map›Paper›PMID 38004705›Full record

ArticleMicroorganisms2023

A Synthetic Formula Amino Acid Diet Leads to Microbiome Dysbiosis, Reduced Colon Length, Inflammation, and Altered Locomotor Activity in C57BL/6J Mice.

Viviana J Mancilla, Paige N Braden-Kuhle, Kelly N Brice, Allison E Mann, Megan T Williams, Yan Zhang, Michael J Chumley, Robert C Barber, Sabrina N White, Gary W Boehm and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Viviana J MancillaDepartment of Microbiology, Immunology, and Genetics, School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0003-3845-4254
Paige N Braden-KuhleDepartment of Psychology, College of Science and Engineering, Texas Christian University, Fort Worth, TX 76109, USA.
Kelly N BriceDepartment of Psychology, College of Science and Engineering, Texas Christian University, Fort Worth, TX 76109, USA.
Allison E MannDepartment of Microbiology, Immunology, and Genetics, School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Megan T WilliamsDepartment of Microbiology, Immunology, and Genetics, School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Yan ZhangDepartment of Microbiology, Immunology, and Genetics, School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Michael J ChumleyDepartment of Biology, College of Science and Engineering, Texas Christian University, Fort Worth, TX 76109, USA.
Robert C BarberDepartment of Pharmacology and Neuroscience, School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0001-6857-0286
Sabrina N WhiteDepartment of Microbiology, Immunology, and Genetics, School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0002-6773-854X
Gary W BoehmDepartment of Psychology, College of Science and Engineering, Texas Christian University, Fort Worth, TX 76109, USA.
Michael S AllenDepartment of Microbiology, Immunology, and Genetics, School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0003-2293-8078
University of North Texas · USTexas Christian University · US

Funding

Texas Minority Health, Research and Outreach (MiHERO)S21MD012472 · NIMHD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JAMBOOR K. VISHWANATHA · 2017 to 2026
$18.0M
UNT Health Science Center IMSDR25GM125587 · NIGMS · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JONES, HARLAN PIERRE · 2018 to 2022
$1.4M
NIGMS NIH HHS R25 GM125587NIGMS NIH HHS R25GM125587NIMHD NIH HHS S21 MD012472NIMHD NIH HHS S21MD012472
6 · The paper itself

Abstract

The effects of synthetic, free-amino acid diets, similar to those prescribed as supplements for (phenylketonuria) PKU patients, on gut microbiota and overall health are not well understood. In the current, multidisciplinary study, we examined the effects of a synthetically-derived, low-fiber, amino acid diet on behavior, cognition, gut microbiome composition, and inflammatory markers. A cohort of 20 male C57BL/6J mice were randomly assigned to either a standard or synthetic diet (

Indexed as

butyratefibergut-brain axisinflammationmouse modelprebioticsSCFAsynthetic diet

Identifiers

PMID38004705
PMCPMC10673175
OpenAlexW4388296049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.