Evidence map›Paper›PMID 38004588›Full record

ArticlePharmaceutics2023

Carob Extract (

Aleksandar Rašković, Nikola Martić, Ana Tomas, Bojana Andrejić-Višnjić, Milana Bosanac, Marko Atanasković, Marko Nemet, Radmila Popović, Marko Krstić, Saša Vukmirović and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Carob (Foods (Basel, Switzerland) · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Aleksandar RaškovićDepartment of Pharmacology, Toxicology, and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.
Nikola MartićDepartment of Pharmacology, Toxicology, and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.
Ana TomasDepartment of Pharmacology, Toxicology, and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.ORCID 0000-0003-2361-872X
Bojana Andrejić-VišnjićDepartment of Histology and Embryology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.
Milana BosanacDepartment of Histology and Embryology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.ORCID 0000-0002-9560-7176
Marko AtanaskovićFaculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.ORCID 0000-0003-2678-8062
Marko NemetFaculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.ORCID 0000-0003-1485-9214
Radmila PopovićFaculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.
Marko KrstićFaculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0003-1947-4794
Saša VukmirovićDepartment of Pharmacology, Toxicology, and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.ORCID 0000-0002-3271-4492
Nebojša StilinovićDepartment of Pharmacology, Toxicology, and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.ORCID 0000-0003-0118-9418
University of Novi Sad · RSUniversity of Belgrade · RS

Funding

Provincial Secretariat for Higher Education and Scientific Research of Vojvodina 142-451-2574/2021-01
6 · The paper itself

Abstract

Dyslipidemia and obesity are recognized as two of the major global health issues and main risk factors for coronary heart disease and cerebrovascular disease. In recent years, carob has shown certain antioxidant and anti-dyslipidemic potential. In this study, Wistar rats were fed with a standard and cholesterol-enriched diet and treated orally with carob extract and simvastatin for four weeks. After sacrifice, blood samples were collected for biochemical analysis, and liver tissue was taken for histological and immunohistochemical assessment. Weight gain was significantly higher in groups fed with cholesterol-fortified granules; total cholesterol was found to be significantly lower in the hypercholesterolemic groups treated with simvastatin and simvastatin/carob combined regimens compared with hypercholesterolemic animals treated with saline (

Indexed as

adiponectincarob extractCYP2E1dyslipidemiahigh-fat diet-fed rat modelIba1leptinobesity

Identifiers

PMID38004588
PMCPMC10674595
OpenAlexW4388635308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.