Evidence map›Paper›PMID 38004576›Full record

ArticlePharmaceutics2023

Oral Drug Absorption and Drug Disposition in Critically Ill Cardiac Patients.

Lars-Olav Harnisch, Jürgen Brockmöller, Anne Hapke, Juliane Sindern, Ellen Bruns, Ruben Evertz, Karl Toischer, Bernhard C Danner, Dorothee Mielke, Veit Rohde and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lars-Olav HarnischDepartment of Anesthesiology, University of Göttingen Medical Center, 37075 Göttingen, Germany.ORCID 0000-0002-4935-3240
Jürgen BrockmöllerDepartment of Clinical Pharmacology, University of Göttingen Medical Center, 37075 Göttingen, Germany.ORCID 0000-0002-8854-1340
Anne HapkeDepartment of Neurosurgery, University of Göttingen Medical Center, 37075 Göttingen, Germany.
Juliane SindernDepartment of Neurosurgery, University of Göttingen Medical Center, 37075 Göttingen, Germany.
Ellen BrunsDepartment of Clinical Pharmacology, University of Göttingen Medical Center, 37075 Göttingen, Germany.
Ruben EvertzDepartment of Cardiology and Pneumology, University of Göttingen Medical Center, 37075 Göttingen, Germany.ORCID 0000-0002-5904-4652
Karl ToischerDepartment of Cardiology and Pneumology, University of Göttingen Medical Center, 37075 Göttingen, Germany.
Bernhard C DannerDepartment of Cardiac, Thoracic and Vascular Surgery, University of Göttingen Medical Center, 37075 Göttingen, Germany.
Dorothee MielkeDepartment of Neurosurgery, University of Göttingen Medical Center, 37075 Göttingen, Germany.ORCID 0000-0002-1462-4864
Veit RohdeDepartment of Neurosurgery, University of Göttingen Medical Center, 37075 Göttingen, Germany.ORCID 0000-0003-3014-4307
Tammam AbboudDepartment of Neurosurgery, University of Göttingen Medical Center, 37075 Göttingen, Germany.
University of Göttingen · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: In critically ill cardiac patients, parenteral and enteral food and drug administration routes may be used. However, it is not well known how drug absorption and metabolism are altered in this group of adult patients. Here, we analyze drug absorption and metabolism in patients after cardiogenic shock using the pharmacokinetics of therapeutically indicated esomeprazole. (2) Methods: The pharmacokinetics of esomeprazole were analyzed in a consecutive series of patients with cardiogenic shock and controls before and after elective cardiac surgery. Esomeprazole was administered orally or with a nasogastric tube and once as an intravenous infusion. (3) Results: The maximum plasma concentration and AUC of esomeprazole were, on average, only half in critically ill patients compared with controls (

Indexed as

cardiogenic shockenteral medicationesomeprazoleintensive care medication

Identifiers

PMID38004576
PMCPMC10674156
OpenAlexW4388446546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.