ArticlePharmaceutics2023
Tri-Layer Core-Shell Fibers from Coaxial Electrospinning for a Modified Release of Metronidazole.
Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 73 citations in OpenAlex.
- Magnetically responsive electrospun fibers as programmable bioactive scaffolds: From formulation design to magnetically triggered therapy and regeneration.Bioactive materials · 2027Review
- Laser Modification of Functional Fibers Obtained by Electrospinning.Materials (Basel, Switzerland) · 2025Article
- A Modified Triaxial Electrospinning for a High Drug Encapsulation Efficiency of Curcumin in Ethylcellulose.Pharmaceutics · 2025Article
- Electrospun Fiber Mats with Metronidazole: Design, Evaluation, and Release Kinetics.The journal of physical chemistry. B · 2025Article
- Study on Deposition of Coaxial Electrospinning Fibers by Coaxial Auxiliary Flow Field.Polymers · 2025Article
- Advanced applications of smart electrospun nanofibers in cancer therapy: With insight into material capabilities and electrospinning parameters.International journal of pharmaceutics: X · 2024Review
- Core-Sheath Fibers via Single-Nozzle Spinneret Electrospinning of Emulsions and Homogeneous Blend Solutions.Materials (Basel, Switzerland) · 2024Review
- Advances in Electrospun Nanofiber Membranes for Dermatological Applications: A Review.Molecules (Basel, Switzerland) · 2024Review
- Wound Dressing with Electrospun Core-Shell Nanofibers: From Material Selection to Synthesis.Polymers · 2024Review
- Alginate-Based Electrospun Nanofibers and the Enabled Drug Controlled Release Profiles: A Review.Biomolecules · 2024Review
- A Color-Detectable Vitamin C Controlled-Release System Fabricated Using Electrospinning.Polymers · 2024Article
- Recent progress of electrospun nanofibers as burning dressings.RSC advances · 2024Review
- Electrospun Fenoprofen/Polycaprolactone @ Tranexamic Acid/Hydroxyapatite Nanofibers as Orthopedic Hemostasis Dressings.Nanomaterials (Basel, Switzerland) · 2024Article
- Review
- Research Advances in Superabsorbent Polymers.Polymers · 2024Review
- Recent Advances in Electrospinning Techniques for Precise Medicine.Cyborg and bionic systems (Washington, D.C.) · 2024Review
- Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery.Frontiers in bioengineering and biotechnology · 2024Article
- Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications.Frontiers in bioengineering and biotechnology · 2024Review
- Electrospun radially oriented berberine-PHBV nanofiber dressing patches for accelerating diabetic wound healing.Regenerative biomaterials · 2024Article
- Flame spray pyrolyzed carbon-encapsulated Au/FeFrontiers in bioengineering and biotechnology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymers are the backbone of drug delivery. Electrospinning has greatly enriched the strategies that have been explored for developing novel drug delivery systems using polymers during the past two decades. In this study, four different kinds of polymers, i.e., the water-soluble polymer poly (vinyl alcohol) (PVA), the insoluble polymer poly(ε-caprolactone) (PCL), the insoluble polymer Eudragit RL100 (ERL100) and the pH-sensitive polymer Eudragit S100 (ES100) were successfully converted into types of tri-layer tri-polymer core-shell fibers through bi-fluid coaxial electrospinning. During the coaxial process, the model drug metronidazole (MTD) was loaded into the shell working fluid, which was an emulsion. The micro-formation mechanism of the tri-layer core-shell fibers from the coaxial emulsion electrospinning was proposed. Scanning electron microscope and transmission electron microscope evaluations verified the linear morphology of the resultant fibers and their obvious tri-layer multiple-chamber structures. X-ray diffraction and Fourier transform infrared spectroscopy measurements demonstrated that the drug MTD presented in the fibers in an amorphous state and was compatible with the three polymeric matrices. In vitro dissolution tests verified that the three kinds of polymer could act in a synergistic manner for a prolonged sustained-release profile of MTD in the gut. The drug controlled-release mechanisms were suggested in detail. The protocols reported here pioneer a new route for creating a tri-layer core-shell structure from both aqueous and organic solvents, and a new strategy for developing advanced drug delivery systems with sophisticated drug controlled-release profiles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.