Discovery and Characterization of a Dual-Function Peptide Derived from Bitter Gourd Seed Protein Using Two Orthogonal Bioassay-Guided Fractionations Coupled with In Silico Analysis.

Wei-Ting Hung, Christoper Caesar Yudho Sutopo, Mei-Li Wu, Jue-Liang Hsu

Open access · goldAbstract read

In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

1.1field-weighted citation impact, top 22% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

Gastrointestinal digestion enhances the release of bioactive peptides from yogurt.European journal of nutrition · 2026
Article
Identification of VAYPQCV, a Gastrointestinally Stable Competitive DPP-IV Inhibitory Peptide from Bitter Leaf (Vernonia amygdalina).Plant foods for human nutrition (Dordrecht, Netherlands) · 2026
Article
Exploring the Antidiabetic and Antihypertensive Potential of Peptides Derived from Bitter Melon Seed Hydrolysate.Biomedicines · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wei-Ting HungDepartment of Food Science, National Pingtung University of Science and Technology, Pingtung 912, Taiwan.

Christoper Caesar Yudho SutopoDepartment of Tropical Agriculture and International Cooperation, National Pingtung University of Science and Technology, Pingtung 912, Taiwan.ORCID 0000-0002-8611-9808

Mei-Li WuDepartment of Food Science, National Pingtung University of Science and Technology, Pingtung 912, Taiwan.

Jue-Liang HsuDepartment of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan.ORCID 0000-0002-6771-6690

National Pingtung University of Science and Technology · TW

Funding

Ministry of Science and Technology (Taiwan) MOST 111-2113-M-020-001

6 · The paper itself

Abstract

The hydrolysate of bitter gourd seed protein, digested by the combined gastrointestinal proteases (BGSP-GPs), exhibited the most potent inhibition on angiotensin-I-converting enzyme (ACE) with an IC

Indexed as

ACE inhibitory peptidebitter gourd seedsDPP4 inhibitory peptidein silico analysisLC-MS/MS

Identifiers

PMID38004494

DOI10.3390/ph16111629

PMCPMC10674851

OpenAlexW4388832786

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.