Evidence map›Paper›PMID 38004462›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Repurposing Synthetic Congeners of a Natural Product Aurone Unveils a Lead Antitumor Agent Inhibiting Folded P-Loop Conformation of MET Receptor Tyrosine Kinase.

Ahmed H E Hassan, Cai Yi Wang, Cheol Jung Lee, Hye Rim Jeon, Yeonwoo Choi, Suyeon Moon, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Kazem Mahmoud and 3 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Ahmed H E HassanDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0002-1048-6281
Cai Yi WangNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Cheol Jung LeeDepartment of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Hye Rim JeonDepartment of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Yeonwoo ChoiDepartment of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Suyeon MoonDepartment of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Chae Hyeon LeeDepartment of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Yeon Ju KimDepartment of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Soo Bin ChoDepartment of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Kazem MahmoudDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City 11829, Egypt.ORCID 0000-0002-7044-0015
Selwan M El-SayedDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0003-3962-6409
Sang Kook LeeNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0002-4306-7024
Yong Sup LeeMedicinal Chemistry Laboratory, Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea.ORCID 0000-0001-6523-6979
Kyung Hee University · KRMansoura University · EGSeoul National University · KREgyptian Russian University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A library of 24 congeners of the natural product sulfuretin were evaluated against nine panels representing nine cancer diseases. While sulfuretin elicited very weak activities at 10 µM concentration, congener

Indexed as

antitumor agentsapoptosisauronecell cycle arrestcolon cancerMET kinasenatural products congenerssulfuretin

Identifiers

PMID38004462
PMCPMC10675456
OpenAlexW4388639017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.