Evidence map›Paper›PMID 38004458›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Design, Synthesis, In Vitro, and In Silico Studies of New

Waheed A Zaki, Selwan M El-Sayed, Mohamed Alswah, Ahmed El-Morsy, Ashraf H Bayoumi, Abrahman S Mayhoub, Walaa H Moustafa, Aeshah A Awaji, Eun Joo Roh, Ahmed H E Hassan and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Waheed A ZakiDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.
Selwan M El-SayedDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0003-3962-6409
Mohamed AlswahDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.
Ahmed El-MorsyDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.ORCID 0000-0003-1549-7673
Ashraf H BayoumiDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.
Abrahman S MayhoubDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.
Walaa H MoustafaMicrobiology and Immunology Department, Faculty of Pharmacy, Helwan University, Cairo 19448, Egypt.
Aeshah A AwajiDepartment of Biology, Faculty of Science, University College of Taymaa, University of Tabuk, Tabuk 71491, Saudi Arabia.
Eun Joo RohChemical and Biological Integrative Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Ahmed H E HassanDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0002-1048-6281
Kazem MahmoudDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City 11829, Egypt.ORCID 0000-0002-7044-0015
Al-Azhar University · EGMansoura University · EGBio-Medical Science (South Korea) · KREgyptian Russian University · EGHelwan University · EGUniversity of Tabuk · SA

Funding

Korea Institute of Science and Technology 2E32333National Research Council of Science and Technology CAP23011-100
6 · The paper itself

Abstract

CDK2 is a key player in cell cycle processes. It has a crucial role in the progression of various cancers. Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) are two common cancers that affect humans worldwide. The available therapeutic options suffer from many drawbacks including high toxicity and decreased specificity. Therefore, there is a need for more effective and safer therapeutic agents. A series of new pyrazolo[3,4-

Indexed as

anticancer agentsCDK2colorectal cancerliver cancerpyrazolo[3,4-d]pyrimidine analogs

Identifiers

PMID38004458
PMCPMC10674233
OpenAlexW4388635115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.