Evidence map›Paper›PMID 38004454›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Development and Evaluation of Solid Dispersion-Based Sublingual Films of Nisoldipine.

Yahya Alhamhoom, Abhay Sharma, Shivakumar Hagalavadi Nanjappa, Avichal Kumar, Anas Alshishani, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana, Mohamed Rahamathulla

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Targeting mitochondria and programmed cell death as potential interventions for metastatic castration-resistant prostate cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Yahya AlhamhoomDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, Al Faraa, Abha 62223, Saudi Arabia.ORCID 0000-0002-8368-9047
Abhay SharmaDepartment of Pharmaceutics, KLE College of Pharmacy, Bengaluru 560010, India.
Shivakumar Hagalavadi NanjappaDepartment of Pharmaceutics, KLE College of Pharmacy, Bengaluru 560010, India.ORCID 0000-0003-1596-9941
Avichal KumarDepartment of Pharmaceutics, KLE College of Pharmacy, Bengaluru 560010, India.ORCID 0000-0003-3893-3407
Anas AlshishaniFaculty of Pharmacy, Zarqa University, Zarqa 13132, Jordan.ORCID 0000-0002-0040-5492
Mohammed Muqtader AhmedDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdul Aziz University, Al Kharj 11942, Saudi Arabia.
Syeda Ayesha FarhanaDepartment of Pharmaceutics, Unaizah College of Pharmacy, Qassim University, Unaizah 51911, Saudi Arabia.ORCID 0000-0001-8154-7718
Mohamed RahamathullaDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, Al Faraa, Abha 62223, Saudi Arabia.ORCID 0000-0001-8826-3718
KLE University · INKing Khalid University · SAPrince Sattam Bin Abdulaziz University · SAQassim University · SAZarqa University · JO

Funding

Deanship of Scientific Research at King Khalid University for supporting the funding for this work through Large Groups RGP. 2/264/44].
6 · The paper itself

Abstract

Nisoldipine (NIS) is a calcium channel blocker that exhibits poor bioavailability (~5%) due to low aqueous solubility and presystemic metabolism in the gut wall. In this context, the present work aimed to develop NIS solid dispersion (NISSD)-based sublingual films using solvent casting technique to improve the dissolution. Phase solubility studies indicated that Soluplus

Indexed as

hypertension managementin vitro studynisoldipinephase solubilitysolid dispersionsublingual films

Identifiers

PMID38004454
PMCPMC10674845
OpenAlexW4388526331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.