Evidence map›Paper›PMID 38004430›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Novel Derivatives of Quinoxaline-2-carboxylic Acid 1,4-Dioxides as Antimycobacterial Agents: Mechanistic Studies and Therapeutic Potential.

Svetlana G Frolova, Aleksey A Vatlin, Dmitry A Maslov, Buhari Yusuf, Galina I Buravchenko, Olga B Bekker, Ksenia M Klimina, Svetlana V Smirnova, Lidia M Shnakhova, Irina K Malyants and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. A Quinoxaline 1,4-Dioxide Activates DNA Repair Systems inInternational journal of molecular sciences · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 3 countries.

Svetlana G FrolovaLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.
Aleksey A VatlinLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.ORCID 0000-0002-6499-3908
Dmitry A MaslovDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-4296-5815
Buhari YusufState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.ORCID 0000-0002-4021-4519
Galina I BuravchenkoGause Institute of New Antibiotics, 119021 Moscow, Russia.
Olga B BekkerLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.ORCID 0000-0003-2015-0025
Ksenia M KliminaLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.
Svetlana V SmirnovaLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.
Lidia M ShnakhovaInstitute for Regenerative Medicine, Department of Dermatology and Venereology, Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Irina K MalyantsLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency (Lopukhin FRCC PCM), 119435 Moscow, Russia.
Arseniy I LashkinFederal Research and Clinical Center of Physical-Сhemical Medicine, 119435 Moscow, Russia.
Xirong TianState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Md Shah AlamState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
George V ZatonskyGause Institute of New Antibiotics, 119021 Moscow, Russia.
Tianyu ZhangState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.ORCID 0000-0001-5647-6014
Andrey E ShchekotikhinGause Institute of New Antibiotics, 119021 Moscow, Russia.
Valery N DanilenkoLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.ORCID 0000-0001-5780-0621
Chinese Academy of Sciences · CNVavilov Institute of General Genetics · RUGause Institute of New Antibiotics Russian Academy of Medical Sciences · RUFederal Medical-Biological Agency · RULomonosov Moscow State University · RUMoscow Institute of Physics and Technology · RUPeoples' Friendship University of Russia · RUSechenov University · RUStanford University · US

Funding

National Key R&D Program of China 2021YFA1300900National Natural Science Foundation of China 82061138019Russian Science Foundation 21-45-00018
6 · The paper itself

Abstract

The World Health Organization (WHO) reports that tuberculosis (TB) is one of the top 10 leading causes of global mortality. The increasing incidence of multidrug-resistant TB highlights the urgent need for an intensified quest to discover innovative anti-TB medications In this study, we investigated four new derivatives from the quinoxaline-2-carboxylic acid 1,4-dioxide class. New 3-methylquinoxaline 1,4-dioxides with a variation in substituents at positions 2 and 6(7) were synthesized via nucleophilic aromatic substitution with amines and assessed against a

Indexed as

antimicrobial activityderivatives of quinoxaline-2-carboxylic acid 1,4-dioxidedrug resistanceM. smegmatis mutantsM. tuberculosis

Identifiers

PMID38004430
PMCPMC10675252
OpenAlexW4388422864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.