Evidence map›Paper›PMID 38004417›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study.

Awaji Y Safhi, Waqar Siddique, Muhammad Zaman, Rai Muhammad Sarfraz, Muhammad Shafeeq Ur Rahman, Asif Mahmood, Ahmad Salawi, Fahad Y Sabei, Abdullah Alsalhi, Khalid Zoghebi

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Awaji Y SafhiDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.ORCID 0000-0002-2184-4339
Waqar SiddiqueRiphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Lahore 54000, Pakistan.
Muhammad ZamanFaculty of Pharmaceutical Sciences, University of Central Punjab, Lahore 54590, Pakistan.ORCID 0000-0003-1768-2979
Rai Muhammad SarfrazCollege of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.ORCID 0000-0003-3121-651X
Muhammad Shafeeq Ur RahmanFaculty of Pharmaceutical Sciences, University of Central Punjab, Lahore 54590, Pakistan.
Asif MahmoodDepartment of Pharmacy, University of Chakwal, Chakwal 48800, Pakistan.ORCID 0000-0002-4468-1069
Ahmad SalawiDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.ORCID 0000-0001-6342-284X
Fahad Y SabeiDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.ORCID 0000-0002-1412-5299
Abdullah AlsalhiDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.ORCID 0000-0002-1994-7179
Khalid ZoghebiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.ORCID 0000-0002-7401-5227

Funding

Deputyship for Research& Innovation, Ministry of Education in Saudi Arabia ISP22-20
6 · The paper itself

Abstract

A migraine is a condition of severe headaches, causing a disturbance in the daily life of the patient. The current studies were designed to develop immediate-release polymeric buccal films of Eletriptan Hydrobromide (EHBR) and Itopride Hydrochloride (ITHC) to improve their bioavailability and, hence, improve compliance with the patients of migraines and its associated symptoms. The prepared films were evaluated for various in vitro parameters, including surface morphology, mechanical strength, disintegration test (DT), total dissolving time (TDT), drug release and drug permeation, etc., and in vivo pharmacokinetic parameters, such as area under curve (AUC), mean residence time (MRT), half-life (t

Indexed as

buccal filmdrug deliveryimmediate dosage formplasticizersurfactant

Identifiers

PMID38004417
PMCPMC10674159

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.