Evidence map›Paper›PMID 38004388›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAF

Lamya H Al-Wahaibi, Mohamed Hisham, Hesham A Abou-Zied, Heba A Hassan, Bahaa G M Youssif, Stefan Bräse, Alaa M Hayallah, Mohamed Abdel-Aziz

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lamya H Al-WahaibiDepartment of Chemistry, College of Sciences, Princess Nourah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia.
Mohamed HishamPharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City 61111, Egypt.ORCID 0000-0002-5467-8939
Hesham A Abou-ZiedPharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City 61111, Egypt.ORCID 0000-0001-6993-3325
Heba A HassanMedicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Bahaa G M YoussifPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
Stefan BräseInstitute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.ORCID 0000-0003-4845-3191
Alaa M HayallahPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.ORCID 0000-0001-9517-8650
Mohamed Abdel-AzizMedicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

Funding

Princess Nourah bint Abdulrahman University PNURSP2023R3
6 · The paper itself

Abstract

A novel series of hybrid compounds comprising quinazolin-4-one and 3-cyanopyridin-2-one structures has been developed, with dual inhibitory actions on both EGFR and BRAF

Indexed as

3-cyanopyridin-2-oneanti-cancerBRAFV600EdockingEGFRquinazolin-4-one

Identifiers

PMID38004388
PMCPMC10674657

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.