Evidence map›Paper›PMID 38004240›Full record

ArticleNutrients2023

Lactate Conversion by Lactate Dehydrogenase B Is Involved in Beige Adipocyte Differentiation and Thermogenesis in Mice.

Bin Guo, Hui Shu, Ling Luo, Xiangpeng Liu, Yue Ma, Jie Zhang, Zhiwei Liu, Yong Zhang, Lei Fu, Tongxing Song and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Bin GuoThe Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Dongguan 523018, China.
Hui ShuCambridge-Suda Genomic Resource Center, Soochow University, Suzhou 215123, China.
Ling LuoCambridge-Suda Genomic Resource Center, Soochow University, Suzhou 215123, China.
Xiangpeng LiuCambridge-Suda Genomic Resource Center, Soochow University, Suzhou 215123, China.
Yue MaCambridge-Suda Genomic Resource Center, Soochow University, Suzhou 215123, China.
Jie ZhangCambridge-Suda Genomic Resource Center, Soochow University, Suzhou 215123, China.
Zhiwei LiuCambridge-Suda Genomic Resource Center, Soochow University, Suzhou 215123, China.
Yong ZhangCambridge-Suda Genomic Resource Center, Soochow University, Suzhou 215123, China.
Lei FuWisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.
Tongxing SongCollege of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0002-0969-3689
Yixue QiaoWisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.
Chi ZhangCambridge-Suda Genomic Resource Center, Soochow University, Suzhou 215123, China.
Soochow University · CNXi’an Jiaotong-Liverpool University · CNDongguan People’s Hospital · CNHuazhong Agricultural University · CN

Funding

China Postdoctoral Science Foundation 2023M731545Dongguan high-level hospital construction project 20231800928372Hubei Provincial Natural Science Foundation of China 2023AFB1052National Natural Science Foundation of China 32202969, 32102561 and 82202654SIP High-Quality Innovation Platform for Chronic Diseases YZCXPT2022203
6 · The paper itself

Abstract

Adipose tissue (AT) is the primary reservoir of lipid, the major thermogenesis organ during cold exposure, and an important site for lactate production. However, the utilization of lactate as a metabolic substrate by adipocytes, as well as its potential involvement in the regulation of adipocyte thermogenesis, remain unappreciated. In vitro experiments using primary stromal vascular fraction preadipocytes isolated from mouse inguinal white adipose tissue (iWAT) revealed that lactate dehydrogenase B (LDHB), the key glycolytic enzyme that catalyzes the conversion of lactate to pyruvate, is upregulated during adipocyte differentiation, downregulated upon chronic cold stimulation, and regained after prolonged cold exposure. In addition, the global knockout of

Indexed as

Adipocytes, BeigeAdipose TissueAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsIsoenzymesLactic AcidL-Lactate DehydrogenaseMiceMice, Inbred C57BLThermogenesisIsoenzymeslactate dehydrogenase 1Lactic AcidL-Lactate Dehydrogenasebeige adipocytelactate dehydrogenase B (LDHB)thermogenesis

Identifiers

PMID38004240
PMCPMC10674895
OpenAlexW4388824006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.